1dde
From Proteopedia
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'''STRUCTURE OF THE DNAG CATALYTIC CORE''' | '''STRUCTURE OF THE DNAG CATALYTIC CORE''' | ||
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[[Category: Roche, D D.]] | [[Category: Roche, D D.]] | ||
[[Category: 3-helix bundle]] | [[Category: 3-helix bundle]] | ||
| - | [[Category: | + | [[Category: Dna-binding protein]] |
| - | [[Category: | + | [[Category: Primase]] |
| - | [[Category: | + | [[Category: Replication protein]] |
| - | [[Category: | + | [[Category: Rna polymerase]] |
| - | [[Category: | + | [[Category: Toprim]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:43:13 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:43, 2 May 2008
STRUCTURE OF THE DNAG CATALYTIC CORE
Overview
All cellular organisms use specialized RNA polymerases called "primases" to synthesize RNA primers for the initiation of DNA replication. The high-resolution crystal structure of a primase, comprising the catalytic core of the Escherichia coli DnaG protein, was determined. The core structure contains an active-site architecture that is unrelated to other DNA or RNA polymerase palm folds, but is instead related to the "toprim" fold. On the basis of the structure, it is likely that DnaG binds nucleic acid in a groove clustered with invariant residues and that DnaG is positioned within the replisome to accept single-stranded DNA directly from the replicative helicase.
About this Structure
1DDE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of the RNA polymerase domain of E. coli primase., Keck JL, Roche DD, Lynch AS, Berger JM, Science. 2000 Mar 31;287(5462):2482-6. PMID:10741967 Page seeded by OCA on Fri May 2 13:43:13 2008
