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1sqw

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Revision as of 11:32, 24 December 2020

Crystal structure of KD93, a novel protein expressed in the human pro

Structural highlights

1sqw is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	novel gene (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NIP7_HUMAN] Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of a novel hypothetical protein, KD93, expressed in human hematopoietic stem/progenitor cells, was determined at 1.9A resolution using the multiple-wavelength anomalous dispersion (MAD) method. The protein KD93, which is encoded by the open reading frame HSPC031, is a NIP7 homologue and belongs to the UPF0113 family. The structural and functional information for the group of homologues has not yet been determined. Crystallographic analysis revealed that the overall fold of KD93 consists of two interlinked alpha/beta domains. Structure-based homology analysis with DALI revealed that the C domain of KD93 matches the PUA domain of some RNA modification enzymes, especially that of archaeosine tRNA-ribosyltransferase (ArcTGT), which suggests that its possible molecular function is related to RNA binding. The difference between the RNA binding regions of KD93 and ArcTGT in amino acid constitution and surface electrostatic potential indicate that they may have different RNA binding modes. The N domain of KD93 is a unique structure with no obvious similarity to other proteins with known three-dimensional structures. The high-resolution structure of KD93 provides a first view of a member of the family of hypothetical proteins. And the structure provides a framework to deduce and assay the molecular function of other proteins of the UPF0113 family.

Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells.,Liu JF, Wang XQ, Wang ZX, Chen JR, Jiang T, An XM, Chang WR, Liang DC J Struct Biol. 2004 Dec;148(3):370-4. PMID:15522784^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Morello LG, Coltri PP, Quaresma AJ, Simabuco FM, Silva TC, Singh G, Nickerson JA, Oliveira CC, Moore MJ, Zanchin NI. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. PLoS One. 2011;6(12):e29174. doi: 10.1371/journal.pone.0029174. Epub 2011 Dec 16. PMID:22195017 doi:http://dx.doi.org/10.1371/journal.pone.0029174
↑ Liu JF, Wang XQ, Wang ZX, Chen JR, Jiang T, An XM, Chang WR, Liang DC. Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. J Struct Biol. 2004 Dec;148(3):370-4. PMID:15522784 doi:10.1016/j.jsb.2004.06.010

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sqw"

@@ Line 1: / Line 1: @@
 ==Crystal structure of KD93, a novel protein expressed in the human pro==
-<StructureSection load='1sqw' size='340' side='right' caption='[[1sqw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='1sqw' size='340' side='right'caption='[[1sqw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1sqw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1sqw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SQW FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">novel gene ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqw OCA], [http://pdbe.org/1sqw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sqw RCSB], [http://www.ebi.ac.uk/pdbsum/1sqw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqw ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqw OCA], [http://pdbe.org/1sqw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sqw RCSB], [http://www.ebi.ac.uk/pdbsum/1sqw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqw ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: An, X M]]
 [[Category: Chan, W R]]

1sqw

From Proteopedia

Revision as of 11:32, 24 December 2020

Crystal structure of KD93, a novel protein expressed in the human pro

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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