2f3k
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(New page: 200px<br /> <applet load="2f3k" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f3k, resolution 1.599Å" /> '''Substrate envelope...)
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Revision as of 12:40, 8 November 2007
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Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease
Overview
In our previous crystallographic studies of human immunodeficiency virus, type 1 (HIV-1) protease-substrate complexes, we described a conserved, "envelope" that appears to be important for substrate recognition and the, selection of drug-resistant mutations. In this study, the complex of HIV-1, protease with the inhibitor RO1 was determined and comparison with the, substrate envelope provides a rationale for mutational patterns.
About this Structure
2F3K is a Single protein structure of sequence from Human immunodeficiency virus 1 with PO4 and RO1 as ligands. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
Reference
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872
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