1tfu

From Proteopedia

(Difference between revisions)

Revision as of 11:51, 24 December 2020

phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis

Structural highlights

1tfu is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	COAD, KDTB, RV2965C, MT3043, MTCY349.22, U0002E, MB2989C ("Bacillus tuberculosis" (Zopf 1883) Klein 1884)
Activity:	Pantetheine-phosphate adenylyltransferase, with EC number 2.7.7.3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[COAD_MYCTU] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in prokaryotic coenzyme A (CoA) biosynthesis, directing the transfer of an adenylyl group from ATP to 4'-phosphopantetheine (Ppant) to yield dephospho-CoA (dPCoA). The crystal structures of Escherichia coli PPAT bound to its substrates, product, and inhibitor revealed an allosteric hexameric enzyme with half-of-sites reactivity, and established an in-line displacement catalytic mechanism. To provide insight into the mechanism of ligand binding we solved the apoenzyme (Apo) crystal structure of PPAT from Mycobacterium tuberculosis. In its Apo form, PPAT is a symmetric hexamer with an open solvent channel. However, ligand binding provokes asymmetry and alters the structure of the solvent channel, so that ligand binding becomes restricted to one trimer.

Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.,Morris VK, Izard T Protein Sci. 2004 Sep;13(9):2547-52. PMID:15322293^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Morris VK, Izard T. Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Protein Sci. 2004 Sep;13(9):2547-52. PMID:15322293 doi:10.1110/ps.04816904

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tfu"

@@ Line 1: / Line 1: @@
 ==phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis==
-<StructureSection load='1tfu' size='340' side='right' caption='[[1tfu]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
+<StructureSection load='1tfu' size='340' side='right'caption='[[1tfu]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1tfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TFU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1tfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TFU FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">COAD, KDTB, RV2965C, MT3043, MTCY349.22, U0002E, MB2989C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfu OCA], [http://pdbe.org/1tfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tfu RCSB], [http://www.ebi.ac.uk/pdbsum/1tfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfu ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfu OCA], [http://pdbe.org/1tfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tfu RCSB], [http://www.ebi.ac.uk/pdbsum/1tfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfu ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Pantetheine-phosphate adenylyltransferase]]
 [[Category: Izard, T]]

1tfu

From Proteopedia

Revision as of 11:51, 24 December 2020

phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox