This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ddw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ddw.gif|left|200px]]
[[Image:1ddw.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ddw |SIZE=350|CAPTION= <scene name='initialview01'>1ddw</scene>, resolution 1.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ddw", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ddw| PDB=1ddw | SCENE= }}
-
|RELATEDENTRY=[[1ddv|1DDV]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ddw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ddw OCA], [http://www.ebi.ac.uk/pdbsum/1ddw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ddw RCSB]</span>
+
-
}}
+
'''HOMER EVH1 DOMAIN UNLIGANDED'''
'''HOMER EVH1 DOMAIN UNLIGANDED'''
Line 30: Line 27:
[[Category: Worley, P F.]]
[[Category: Worley, P F.]]
[[Category: Xiao, B.]]
[[Category: Xiao, B.]]
-
[[Category: pleckstrin homology domain fold]]
+
[[Category: Pleckstrin homology domain fold]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:44:30 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:39:43 2008''
+

Revision as of 10:44, 2 May 2008

Image:1ddw.gif

Template:STRUCTURE 1ddw

HOMER EVH1 DOMAIN UNLIGANDED


Overview

Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined the crystal structure of the Homer EVH1 domain complexed with a peptide from mGluR (TPPSPF). In contrast to other EVH1 domains, the bound mGluR ligand assumes an unusual conformation in which the side chains of the Ser-Pro tandem are oriented away from the Homer surface, and the Phe forms a unique contact. This unusual binding mode rationalizes conserved features of both Homer and Homer ligands that are not shared by other EVH1 domains. Site-directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer-ligand complexes.

About this Structure

1DDW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition., Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ, Neuron. 2000 Apr;26(1):143-54. PMID:10798399 Page seeded by OCA on Fri May 2 13:44:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ddw"
Personal tools