Limonene-1,2-epoxide hydrolase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The complex of LEH with the valpromide inhibitor shows the valpromide in the LEH active site forming a <scene name='84/846725/Cv/6'>hydrogen bond network</scene>. Water molecule is shown as red sphere.In the LEH hydrolysis mechanism <scene name='84/846725/Cv/4'>residue Asp101 acts as the acid and Asp132 as the base</scene> <ref>PMID:26032250</ref>. | + | The complex of LEH with the valpromide inhibitor shows the valpromide in the LEH active site forming a <scene name='84/846725/Cv/6'>hydrogen bond network</scene>. Water molecule is shown as red sphere. In the LEH hydrolysis mechanism <scene name='84/846725/Cv/4'>residue Asp101 acts as the acid and Asp132 as the base</scene> <ref>PMID:26032250</ref>. |
</StructureSection> | </StructureSection> | ||
Current revision
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3D structures of limonene-1,2-epoxide hydrolase
References
- ↑ Hopmann KH, Hallberg BM, Himo F. Catalytic mechanism of limonene epoxide hydrolase, a theoretical study. J Am Chem Soc. 2005 Oct 19;127(41):14339-47. doi: 10.1021/ja050940p. PMID:16218628 doi:http://dx.doi.org/10.1021/ja050940p
- ↑ Arand M, Hallberg BM, Zou J, Bergfors T, Oesch F, van der Werf MJ, de Bont JA, Jones TA, Mowbray SL. Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. EMBO J. 2003 Jun 2;22(11):2583-92. PMID:12773375 doi:http://dx.doi.org/10.1093/emboj/cdg275
- ↑ Ferrandi EE, Sayer C, Isupov MN, Annovazzi C, Marchesi C, Iacobone G, Peng X, Bonch-Osmolovskaya E, Wohlgemuth R, Littlechild JA, Monti D. Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries. FEBS J. 2015 May 29. doi: 10.1111/febs.13328. PMID:26032250 doi:http://dx.doi.org/10.1111/febs.13328
