7b6k
From Proteopedia
(Difference between revisions)
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==Crystal structure of MurE from E.coli in complex with Z57715447== | ==Crystal structure of MurE from E.coli in complex with Z57715447== | ||
| - | <StructureSection load='7b6k' size='340' side='right'caption='[[7b6k]]' scene=''> | + | <StructureSection load='7b6k' size='340' side='right'caption='[[7b6k]], [[Resolution|resolution]] 1.84Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B6K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7b6k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B6K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6k OCA], [http://pdbe.org/7b6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b6k RCSB], [http://www.ebi.ac.uk/pdbsum/7b6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6k ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZ2:5-cyclohexyl-3-(pyridin-4-yl)-1,2,4-oxadiazole'>SZ2</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6k OCA], [http://pdbe.org/7b6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b6k RCSB], [http://www.ebi.ac.uk/pdbsum/7b6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]] |
| - | [[Category: Bountra C]] | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Edwards | + | [[Category: Bountra, C]] |
| - | [[Category: Fairhead M]] | + | [[Category: Delft, F von]] |
| - | [[Category: Koekemoer L]] | + | [[Category: Douangamath, A]] |
| - | [[Category: Krojer T]] | + | [[Category: Edwards, A M]] |
| - | [[Category: Steindel M]] | + | [[Category: Fairhead, M]] |
| - | [[Category: | + | [[Category: Koekemoer, L]] |
| + | [[Category: Krojer, T]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Steindel, M]] | ||
| + | [[Category: Talon, R]] | ||
| + | [[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase drug target]] | ||
| + | [[Category: Biosynthetic protein]] | ||
| + | [[Category: Fragment screening]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]] | ||
Revision as of 07:03, 30 December 2020
Crystal structure of MurE from E.coli in complex with Z57715447
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Categories: Large Structures | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase | Arrowsmith, C H | Bountra, C | Delft, F von | Douangamath, A | Edwards, A M | Fairhead, M | Koekemoer, L | Krojer, T | Structural genomic | Steindel, M | Talon, R | 6-diaminopimelate ligase cell wall biosynthesis ligase drug target | Biosynthetic protein | Fragment screening | Sgc | Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2
