Tyrosine kinase 3D structures

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*'''NON-RECEPTOR TYROSINE KINASES - nRTK'''
*'''NON-RECEPTOR TYROSINE KINASES - nRTK'''
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-
*'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537)
 
- 
-
**[[1shf]], [[3ua6]] – hTK Fyn SH3 domain – human<br />
 
-
**[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]] - hTK Fyn SH3 domain (mutant)<br />
 
-
**[[1zbj]], [[1nyg]], [[1nyf]] - hTK Fyn SH3 domain – NMR<br />
 
-
**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br />
 
-
**[[4u17]] – hTK Fyn SH2 domain<br />
 
-
**[[2mrj]], [[2mqi]] – hTK Fyn SH2 domain - NMR<br />
 
-
**[[6edf]] - hTK Fyn residues 1-77<br />
 
-
**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br />
 
-
**[[3uf4]] - mTK Fyn SH2+SH3 domains<br />
 
-
**[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant) - chicken - NMR<br />
 
- 
-
*Fyn complex
 
- 
-
**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br />
 
-
**[[1nyf]], [[1nyg]], [[1a0n]], [[1azg]] - hTK Fyn SH3 domain + peptide – NMR<br />
 
-
**[[5zau]] - hTK Fyn SH3 domain + monobody binder – NMR<br />
 
-
**[[1efn]], [[1avz]] - hTK Fyn SH3 domain + HIV Nef protein<br />
 
-
**[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
 
-
**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br />
 
-
**[[4d8d]], [[1efn]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
 
-
**[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br />
 
-
**[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br />
 
-
**[[4u1p]] - hTK Fyn SH2 domain + phosphopeptide<BR />
 
-
**[[1aot]], [[1aou]], [[2mrk]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR />
 
-
**[[2dq7]] – hTK kinase domain + staurosporine<br />
 
*'''Abelson tyrosine kinase'''
*'''Abelson tyrosine kinase'''
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**[[2kk1]] – hTK C terminal – NMR<BR />
**[[2kk1]] – hTK C terminal – NMR<BR />
 +
 +
*'''Ack1 tyrosine kinase''' or '''activated cdc42 kinase 1'''
 +
 +
**[[1u46]], [[4hzr]] - hTK Ack1 kinase domain <br />
 +
**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br />
 +
**[[1u54]] - hTK Ack1 kinase domain + AMPPCP <br />
 +
**[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]] - hTK Ack1 kinase domain + inhibitor<br />
*'''Anaplastic lymphoma kinase (Alk)''' or '''Alk tyrosine kinase receptor'''
*'''Anaplastic lymphoma kinase (Alk)''' or '''Alk tyrosine kinase receptor'''
Line 122: Line 101:
**[[2xp2]], [[6mx8]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br />
**[[2xp2]], [[6mx8]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br />
**[[2yfx]], [[4anq]], [[4ans]], [[5aaa]], [[5aab]], [[5aac]], [[5a9u]], [[5aa8]], [[5aa9]] - hTK kinase domain (mutant) + cancer drug<br />
**[[2yfx]], [[4anq]], [[4ans]], [[5aaa]], [[5aab]], [[5aac]], [[5a9u]], [[5aa8]], [[5aa9]] - hTK kinase domain (mutant) + cancer drug<br />
 +
 +
*'''CapAB tyrosine kinase'''
 +
 +
**[[3bfv]] - SaTK CapA1/CapB2 – ''Staphylococcus aureus'' <br />
 +
**[[2ved]] - SaTK CapA1/CapB2 + Mg + ADP
*'''Csk tyrosine kinase''' or '''C-terminal Src kinase'''
*'''Csk tyrosine kinase''' or '''C-terminal Src kinase'''
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**[[3d7t]], [[3d7u]] - hTK Csk kinase domain (mutant) + C-Src<br />
**[[3d7t]], [[3d7u]] - hTK Csk kinase domain (mutant) + C-Src<br />
**[[1k9a]] - TK Csk C terminal - rat<br />
**[[1k9a]] - TK Csk C terminal - rat<br />
 +
 +
*'''Etk tyrosine kinase'''
 +
 +
**[[3cio]] - EcTK Etk kinase domain – ''Escherichia coli''<br />
 +
 +
*'''Fer tyrosine kinase'''
 +
 +
**[[2kk6]] - hTK Fer SH2 domain – NMR<BR />
 +
**[[6kc4]] - hTK Fer SH2 domain + phosphopeptide<BR />
 +
 +
*'''Fes/Fps tyrosine kinase'''
 +
 +
**[[1wqu]], [[2dcr]] - hTK Fes SH2 domain - NMR<br />
 +
**[[3bkb]] - hTK Fes SH2+kinase domain - NMR<br />
 +
**[[4dyl]] - hTK Fes F-Bar domain <br />
 +
**[[3cbl]] - hTK Fes SH2+kinase domain + peptide<br />
 +
**[[3cd3]] - hTK Fes SH2+kinase domain + peptide + staurosporine<br />
 +
**[[4e93]], [[6jmf]] - hTK TFes + inhibitor<br />
 +
 +
*'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537)
 +
 +
**[[1shf]], [[3ua6]] – hTK Fyn SH3 domain – human<br />
 +
**[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]] - hTK Fyn SH3 domain (mutant)<br />
 +
**[[1zbj]], [[1nyg]], [[1nyf]] - hTK Fyn SH3 domain – NMR<br />
 +
**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br />
 +
**[[4u17]] – hTK Fyn SH2 domain<br />
 +
**[[2mrj]], [[2mqi]] – hTK Fyn SH2 domain - NMR<br />
 +
**[[6edf]] - hTK Fyn residues 1-77<br />
 +
**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br />
 +
**[[3uf4]] - mTK Fyn SH2+SH3 domains<br />
 +
**[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant) - chicken - NMR<br />
 +
 +
*Fyn complex
 +
 +
**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br />
 +
**[[1nyf]], [[1nyg]], [[1a0n]], [[1azg]] - hTK Fyn SH3 domain + peptide – NMR<br />
 +
**[[5zau]] - hTK Fyn SH3 domain + monobody binder – NMR<br />
 +
**[[1efn]], [[1avz]] - hTK Fyn SH3 domain + HIV Nef protein<br />
 +
**[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
 +
**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br />
 +
**[[4d8d]], [[1efn]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
 +
**[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br />
 +
**[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br />
 +
**[[4u1p]] - hTK Fyn SH2 domain + phosphopeptide<BR />
 +
**[[1aot]], [[1aou]], [[2mrk]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR />
 +
**[[2dq7]] – hTK kinase domain + staurosporine<br />
 +
 +
*'''Hck tyrosine kinase''' Domains: SH3 81-137; SH2 119-224; SH1 or kinase+C-terminal 225-525;
 +
 +
**[[3hck]] - hTK Hck SH2 domain - NMR<BR />
 +
**[[1bu1]] - hTK Hck SH3 domain <BR />
 +
**[[4hck]], [[5hck]] - hTK Hck SH3 domain - NMR<BR />
 +
**[[2oj2]], [[2oi3]] - hTK Hck SH3 domain + peptide - NMR<BR />
 +
**[[3rbb]], [[3rea]], [[3reb]] - hTK Hck SH3 domain (mutant) + HIV NEF<BR />
 +
**[[5nuh]] - hTK Hck SH3 domain + SIV NEF<BR />
 +
**[[4orz]] - hTK Hck SH3 domain (mutant) + HIV NEF + single domain antibody<br />
 +
**[[3nhn]] - hTK Hck SH3-SH2-linker domain <BR />
 +
**[[4u5w]] - hTK Hck SH3-SH2 domains + NEF <br />
 +
**[[2c0i]], [[2c0o]], [[2c0t]] - hTK Hck SH3-SH2-SH1 domain + inhibitor<BR />
 +
**[[5h0b]], [[5h0e]], [[5h0g]], [[5h0h]] - hTK Hck SH3-SH2-SH1 domain (mutant) + inhibitor<BR />
 +
**[[2hk5]], [[5zj6]] - hTK Hck kinase domain + inhibitor<BR />
 +
**[[1qcf]], [[3vrz]], [[3vs0]], [[3vs3]], [[3vs4]], [[3vs5]], [[3vs6]], [[3vs7]] - hTK Hck SH3-SH2-kinase-C-terminal domain + inhibitor<BR />
 +
**[[3vry]], [[3vs1]], [[3vs2]] - hTK Hck SH3-SH2-kinase-C-terminal domain (mutant) + inhibitor<BR />
 +
**[[1ad5]] - hTK Hck SH3-SH2-kinase-C-terminal domain + AMPPNP<BR />
 +
**[[2hck]] - hTK Hck SH3-SH2-kinase-C-terminal domain + quercetin<BR />
 +
**[[4lud]], [[4lue]] - hTK Hck SH2+SH3+kinase+C-terrminal domain (mutant) + fluorescent compound<br />
 +
 +
*'''Itk/Tsk tyrosine kinase''' or '''interleukin-2 tyrosine kinase'''; domains – SH2 236-344; SH3 160-236; kinase 357-620
 +
 +
**[[2etz]], [[2eu0]] – hTK Itk SH2 domain + phosphopeptide – NMR<BR />
 +
**[[2yuq]], [[2lmj]] – hTK Itk SH3 domain – NMR<BR />
 +
**[[1sm2]], [[1snu]], [[1snx]] – hTK Itk kinase domain <BR />
 +
**[[3miy]] – hTK Itk kinase domain + cancer drug<BR />
 +
**[[3v5j]], [[3v5l]], [[3v8t]], [[3v8w]] – hTK Itk kinase domain + inhibitor<BR />
 +
**[[3mj1]], [[3mj2]], [[3qgw]], [[3qgy]], [[4hct]], [[4hcu]], [[4hcv]], [[4kio]] – hTK Itk kinase domain (mutant) + inhibitor<BR />
 +
**[[3t9t]] – hTK Itk kinase domain (mutant) + arthritis drug<BR />
 +
**[[2e6i]] – hTK Itk BTK motif – NMR<BR />
 +
**[[4l7s]], [[4m0y]], [[4m0z]], [[4m12]], [[4m13]], [[4m14]], [[4m15]], [[4mf0]], [[4mf1]], [[3v5j]], [[3v5l]], [[3v8t]], [[3v8w]] - hTK Itk kinase domain + inhibitor<br />
 +
**[[4pp9]], [[4ppa]], [[4ppb]], [[4ppc]], [[4pqn]], [[4qd6]], [[4rfm]], [[4kio]] - hTK Itk kinase domain (mutant) + inhibitor<br />
 +
**[[1lui]], [[1luk]], [[1lum]], [[1lun]] – mTK Itk SH2 domain – NMR<BR />
 +
**[[3s9k]] – mTK Itk SH2 domain <BR />
 +
**[[1awj]], [[2rn8]], [[2rna]] – mTK Itk SH3 domain – NMR<BR />
 +
**[[2k79]], [[2k7a]] – mTK Itk SH2+SH3 domains – NMR<BR />
*'''Jak tyrosine kinase''' see [[Janus kinase]]
*'''Jak tyrosine kinase''' see [[Janus kinase]]
 +
 +
*'''Lymphocyte-specific tyrosine kinase Lck''' (Domains: SH3 58-118; SH2 122-225; kinase 230-500)
 +
 +
**[[1kik]], [[1h92]] - hTK Lck SH3 domain – NMR<BR />
 +
**[[2iim]] - hTK Lck SH3 domain<br />
 +
**[[4d8k]], [[1x27]] - hTK Lck SH3-SH2 domain<br />
 +
**[[3lck]] - hTK Lck kinase domain<br />
 +
 +
*Lck complex
 +
 +
**[[1lcj]], [[1lkk]], [[1lkl]] - hTK Lck SH2 domain (mutant) + phosphopeptide<br />
 +
**[[1cwd]], [[1cwe]], [[1ijr]] - hTK Lck SH2 domain + phosphopeptide<br />
 +
**[[1bhf]] - hTK Lck SH2 domain + peptide inhibitor<br />
 +
**[[1fbz]] - hTK Lck SH2 domain + inhibitor<br />
 +
**[[1bhh]] - hTK Lck SH2 domain + T-lymphocyte-specific TK<br />
 +
**[[5mtm]], [[5mtn]] - hTK Lck SH2 domain + monobody<br />
 +
**[[1lck]] - hTK Lck SH3-SH2 domain (mutant) + phosphopeptide<br />
 +
**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br />
 +
**[[1qpj]] - hTK Lck kinase domain + staurosporin<br />
 +
**[[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[2zm1]], [[2zm4]], [[3byo]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3kmm]], [[3ad4]], [[3ad5]], [[3ad6]], [[1qpc]], [[1qpd]], [[1qpe]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br />
 +
**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br />
 +
**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br />
 +
**[[2pl0]] - hTK Lck kinase domain + anti-cancer drug<br />
 +
**[[3kxz]] - hTK Lck kinase domain + probe molecule<br />
 +
**[[1q68]] - hTK Lck residues 6-34 (mutant) + CD4 peptide – NMR<br />
 +
**[[1q69]] - hTK Lck residues 6-34 (mutant) + CD8 – NMR<br />
 +
 +
*'''Lyn tyrosine kinase''' (Domains: SH3 39-101; SH2 115-229; kinase 239-512)
 +
 +
**[[4tzi]] - hTK Lyn SH2 domain <br />
 +
**[[6nmw]] - hTK Lyn SH3 domain <br />
 +
**[[1w1f]] - hTK Lyn SH3 domain – NMR<br />
 +
**[[1wa7]] - hTK Lyn SH3 domain + peptide – NMR<br />
 +
**[[3a4o]] - hTK Lyn residues 233-512 + staurosporine<br />
 +
**[[5xy1]] - hTK Lyn kinase domain + inhibitor<br />
 +
**[[2zv7]] - mTK Lyn kinase domain<br />
 +
**[[2zv8]] - mTK Lyn kinase domain + AMPPNP<br />
 +
**[[2zv9]] - mTK Lyn kinase domain + PP2<br />
 +
**[[2zva]] - mTK Lyn kinase domain + cancer drug<br />
*'''p55-blk tyrosine kinase'''
*'''p55-blk tyrosine kinase'''
**[[1blj]], [[1blk]] - mTK p55-blk SH2 domain – NMR<BR />
**[[1blj]], [[1blk]] - mTK p55-blk SH2 domain – NMR<BR />
 +
 +
*'''Ptk6 tyrosine kinase or breast tumor kinase Brk or tyrosine protein kinase 6'''
 +
 +
**[[1rja]] - hTK Ptk6 SH2 domain – NMR<br />
 +
**[[2kgt]] - hTK Ptk6 SH3 domain – NMR<br />
 +
**[[5d7v]], [[6cz2]] - hTK Ptk6 kinase domain <br />
 +
**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br />
 +
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br />
 +
 +
*'''Ptk7 tyrosine kinase'''
 +
 +
**[[6vg3]] - hTK Ptk7 kinase domain<br />
 +
 +
*'''PtkA tyrosine kinase'''
 +
 +
**[[6f2x]] - TK PtkA – ''Mycobacterium tuberculosis'' - NMR<br />
 +
 +
*'''Pyk2 tyrosine kinase or protein-tyrosine kinase 2-β (Domains: kinase 414-692; FAT 861-1009)'''
 +
 +
**[[3cc6]], [[3fzo]] - hTK Pyk2 kinase domain <br />
 +
**[[3gm2]] - hTK Pyk2 FAT domain<br />
 +
**[[3gm3]] - hTK Pyk2 FAT domain (mutant)<br />
 +
**[[4eku]] – hTK Pyk2 FERM domain<br />
 +
**[[2lk4]] - hTK Pyk2 FAT domain – NMR<br />
 +
 +
*Pyk2 complex
 +
 +
**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br />
 +
**[[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[3et7]], [[5to8]], [[5tob]], [[4h1j]], [[4h1m]] - hTK Pyk2 kinase domain + inhibitor<br />
 +
**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br />
 +
**[[4xek]], [[4xev]], [[4xef]] - hTK Pyk2 FAT domain + leupaxin peptide<br />
 +
**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br />
 +
**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br />
 +
**[[4h1m]] - hFAK2 kinase domain + indole inhibitor<br />
 +
**[[3u3f]] – hFAK2 FAT domain (mutant) + paxillin LD2 motif<br />
 +
 +
*'''Ros tyrosine kinase'''
 +
 +
**[[3zbf]] - hTK Ros kinase domain + cancer drug<br />
 +
**[[4uxl]] - hTK Ros kinase domain + inhibitor<br />
* '''Src tyrosine kinase''' or '''proto-oncogene tyrosine protein kinase''' (Domains: SH3 85-140; SH2 140-251; kinase 253-535)
* '''Src tyrosine kinase''' or '''proto-oncogene tyrosine protein kinase''' (Domains: SH3 85-140; SH2 140-251; kinase 253-535)
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**[[2h8h]] – hTK + inhibitor<br />
**[[2h8h]] – hTK + inhibitor<br />
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-
*'''Lymphocyte-specific tyrosine kinase Lck''' (Domains: SH3 58-118; SH2 122-225; kinase 230-500)
 
- 
-
**[[1kik]], [[1h92]] - hTK Lck SH3 domain – NMR<BR />
 
-
**[[2iim]] - hTK Lck SH3 domain<br />
 
-
**[[4d8k]], [[1x27]] - hTK Lck SH3-SH2 domain<br />
 
-
**[[3lck]] - hTK Lck kinase domain<br />
 
- 
-
*Lck complex
 
- 
-
**[[1lcj]], [[1lkk]], [[1lkl]] - hTK Lck SH2 domain (mutant) + phosphopeptide<br />
 
-
**[[1cwd]], [[1cwe]], [[1ijr]] - hTK Lck SH2 domain + phosphopeptide<br />
 
-
**[[1bhf]] - hTK Lck SH2 domain + peptide inhibitor<br />
 
-
**[[1fbz]] - hTK Lck SH2 domain + inhibitor<br />
 
-
**[[1bhh]] - hTK Lck SH2 domain + T-lymphocyte-specific TK<br />
 
-
**[[5mtm]], [[5mtn]] - hTK Lck SH2 domain + monobody<br />
 
-
**[[1lck]] - hTK Lck SH3-SH2 domain (mutant) + phosphopeptide<br />
 
-
**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br />
 
-
**[[1qpj]] - hTK Lck kinase domain + staurosporin<br />
 
-
**[[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[2zm1]], [[2zm4]], [[3byo]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3kmm]], [[3ad4]], [[3ad5]], [[3ad6]], [[1qpc]], [[1qpd]], [[1qpe]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br />
 
-
**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br />
 
-
**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br />
 
-
**[[2pl0]] - hTK Lck kinase domain + anti-cancer drug<br />
 
-
**[[3kxz]] - hTK Lck kinase domain + probe molecule<br />
 
-
**[[1q68]] - hTK Lck residues 6-34 (mutant) + CD4 peptide – NMR<br />
 
-
**[[1q69]] - hTK Lck residues 6-34 (mutant) + CD8 – NMR<br />
 
*'''Syk - spleen tyrosine kinase'''
*'''Syk - spleen tyrosine kinase'''
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**[[4fl3]] - hSyk kinase domain (mutant) + ANP<br />
**[[4fl3]] - hSyk kinase domain (mutant) + ANP<br />
**[[1a81]] – hSyk tandem SH2 domain + T-cell surface peptide <br />
**[[1a81]] – hSyk tandem SH2 domain + T-cell surface peptide <br />
- 
-
*'''Itk/Tsk tyrosine kinase''' or '''interleukin-2 tyrosine kinase'''; domains – SH2 236-344; SH3 160-236; kinase 357-620
 
- 
-
**[[2etz]], [[2eu0]] – hTK Itk SH2 domain + phosphopeptide – NMR<BR />
 
-
**[[2yuq]], [[2lmj]] – hTK Itk SH3 domain – NMR<BR />
 
-
**[[1sm2]], [[1snu]], [[1snx]] – hTK Itk kinase domain <BR />
 
-
**[[3miy]] – hTK Itk kinase domain + cancer drug<BR />
 
-
**[[3v5j]], [[3v5l]], [[3v8t]], [[3v8w]] – hTK Itk kinase domain + inhibitor<BR />
 
-
**[[3mj1]], [[3mj2]], [[3qgw]], [[3qgy]], [[4hct]], [[4hcu]], [[4hcv]], [[4kio]] – hTK Itk kinase domain (mutant) + inhibitor<BR />
 
-
**[[3t9t]] – hTK Itk kinase domain (mutant) + arthritis drug<BR />
 
-
**[[2e6i]] – hTK Itk BTK motif – NMR<BR />
 
-
**[[4l7s]], [[4m0y]], [[4m0z]], [[4m12]], [[4m13]], [[4m14]], [[4m15]], [[4mf0]], [[4mf1]], [[3v5j]], [[3v5l]], [[3v8t]], [[3v8w]] - hTK Itk kinase domain + inhibitor<br />
 
-
**[[4pp9]], [[4ppa]], [[4ppb]], [[4ppc]], [[4pqn]], [[4qd6]], [[4rfm]], [[4kio]] - hTK Itk kinase domain (mutant) + inhibitor<br />
 
-
**[[1lui]], [[1luk]], [[1lum]], [[1lun]] – mTK Itk SH2 domain – NMR<BR />
 
-
**[[3s9k]] – mTK Itk SH2 domain <BR />
 
-
**[[1awj]], [[2rn8]], [[2rna]] – mTK Itk SH3 domain – NMR<BR />
 
-
**[[2k79]], [[2k7a]] – mTK Itk SH2+SH3 domains – NMR<BR />
 
- 
-
*'''Zap-70 tyrosine kinase''' (Domains: SH2 1-259; kinase 327-606
 
- 
-
**[[4k2r]] – hTK Zap-70<br />
 
-
**[[2ozo]] - hTK Zap-70 (mutant) <br />
 
-
**[[1m61]] - hTK Zap-70 SH2 domain
 
- 
-
*Zap-70 complex
 
- 
-
**[[2oq1]], [[4xz1]] - hTK Zap-70 SH2 domain + peptide<br />
 
-
**[[4xz0]] - hTK Zap-70 SH2 domain + inhibitor<br />
 
-
**[[1u59]] - hTK Zap-70 kinase domain + staurosporine
 
- 
-
*'''Pyk2 tyrosine kinase or protein-tyrosine kinase 2-β (Domains: kinase 414-692; FAT 861-1009)'''
 
- 
-
**[[3cc6]], [[3fzo]] - hTK Pyk2 kinase domain <br />
 
-
**[[3gm2]] - hTK Pyk2 FAT domain<br />
 
-
**[[3gm3]] - hTK Pyk2 FAT domain (mutant)<br />
 
-
**[[4eku]] – hTK Pyk2 FERM domain<br />
 
-
**[[2lk4]] - hTK Pyk2 FAT domain – NMR<br />
 
- 
-
*Pyk2 complex
 
- 
-
**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br />
 
-
**[[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[3et7]], [[5to8]], [[5tob]], [[4h1j]], [[4h1m]] - hTK Pyk2 kinase domain + inhibitor<br />
 
-
**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br />
 
-
**[[4xek]], [[4xev]], [[4xef]] - hTK Pyk2 FAT domain + leupaxin peptide<br />
 
-
**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br />
 
-
**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br />
 
-
**[[4h1m]] - hFAK2 kinase domain + indole inhibitor<br />
 
-
**[[3u3f]] – hFAK2 FAT domain (mutant) + paxillin LD2 motif<br />
 
- 
-
*'''CapAB tyrosine kinase'''
 
- 
-
**[[3bfv]] - SaTK CapA1/CapB2 – ''Staphylococcus aureus'' <br />
 
-
**[[2ved]] - SaTK CapA1/CapB2 + Mg + ADP
 
- 
-
*'''Fer tyrosine kinase'''
 
- 
-
**[[2kk6]] - hTK Fer SH2 domain – NMR<BR />
 
-
**[[6kc4]] - hTK Fer SH2 domain + phosphopeptide<BR />
 
- 
-
*'''Ptk6 tyrosine kinase or breast tumor kinase Brk or tyrosine protein kinase 6'''
 
- 
-
**[[1rja]] - hTK Ptk6 SH2 domain – NMR<br />
 
-
**[[2kgt]] - hTK Ptk6 SH3 domain – NMR<br />
 
-
**[[5d7v]], [[6cz2]] - hTK Ptk6 kinase domain <br />
 
-
**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br />
 
-
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br />
 
- 
-
*'''Ptk7 tyrosine kinase'''
 
- 
-
**[[6vg3]] - hTK Ptk7 kinase domain<br />
 
- 
-
*'''PtkA tyrosine kinase'''
 
- 
-
**[[6f2x]] - TK PtkA – ''Mycobacterium tuberculosis'' - NMR<br />
 
- 
-
*'''Lyn tyrosine kinase''' (Domains: SH3 39-101; SH2 115-229; kinase 239-512)
 
- 
-
**[[4tzi]] - hTK Lyn SH2 domain <br />
 
-
**[[6nmw]] - hTK Lyn SH3 domain <br />
 
-
**[[1w1f]] - hTK Lyn SH3 domain – NMR<br />
 
-
**[[1wa7]] - hTK Lyn SH3 domain + peptide – NMR<br />
 
-
**[[3a4o]] - hTK Lyn residues 233-512 + staurosporine<br />
 
-
**[[5xy1]] - hTK Lyn kinase domain + inhibitor<br />
 
-
**[[2zv7]] - mTK Lyn kinase domain<br />
 
-
**[[2zv8]] - mTK Lyn kinase domain + AMPPNP<br />
 
-
**[[2zv9]] - mTK Lyn kinase domain + PP2<br />
 
-
**[[2zva]] - mTK Lyn kinase domain + cancer drug<br />
 
- 
-
*'''Txk tyrosine kinase'''
 
- 
-
**[[2dm0]] - hTK Txk SH2 domain – NMR<br />
 
- 
-
*'''Yes tyrosine kinase'''
 
- 
-
**[[2hda]] - hTK Yes SH3 domain <br />
 
-
**[[5mtj]] - hTK Yes SH2 domain + monobody<br />
 
*'''Tec tyrosine kinase'''
*'''Tec tyrosine kinase'''
Line 356: Line 380:
**[[1gl5]] - hTK Tec SH3 domain - NMR<br />
**[[1gl5]] - hTK Tec SH3 domain - NMR<br />
-
*'''Fes/Fps tyrosine kinase'''
+
*'''Txk tyrosine kinase'''
-
**[[1wqu]], [[2dcr]] - hTK Fes SH2 domain - NMR<br />
+
**[[2dm0]] - hTK Txk SH2 domain – NMR<br />
-
**[[3bkb]] - hTK Fes SH2+kinase domain - NMR<br />
+
-
**[[4dyl]] - hTK Fes F-Bar domain <br />
+
-
**[[3cbl]] - hTK Fes SH2+kinase domain + peptide<br />
+
-
**[[3cd3]] - hTK Fes SH2+kinase domain + peptide + staurosporine<br />
+
-
**[[4e93]], [[6jmf]] - hTK TFes + inhibitor<br />
+
-
 
+
-
*'''Etk tyrosine kinase'''
+
-
 
+
-
**[[3cio]] - EcTK Etk kinase domain – ''Escherichia coli''<br />
+
-
 
+
-
*'''Wzc tyrosine kinase'''
+
-
 
+
-
**[[3la6]] - EcTK Wzc kinase domain <br />
+
-
 
+
-
*'''Ros tyrosine kinase'''
+
-
 
+
-
**[[3zbf]] - hTK Ros kinase domain + cancer drug<br />
+
-
**[[4uxl]] - hTK Ros kinase domain + inhibitor<br />
+
*'''Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170)
*'''Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170)
Line 389: Line 395:
**[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br />
**[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br />
-
*'''Hck tyrosine kinase''' Domains: SH3 81-137; SH2 119-224; SH1 or kinase+C-terminal 225-525;
+
*'''Wzc tyrosine kinase'''
-
**[[3hck]] - hTK Hck SH2 domain - NMR<BR />
+
**[[3la6]] - EcTK Wzc kinase domain <br />
-
**[[1bu1]] - hTK Hck SH3 domain <BR />
+
-
**[[4hck]], [[5hck]] - hTK Hck SH3 domain - NMR<BR />
+
-
**[[2oj2]], [[2oi3]] - hTK Hck SH3 domain + peptide - NMR<BR />
+
-
**[[3rbb]], [[3rea]], [[3reb]] - hTK Hck SH3 domain (mutant) + HIV NEF<BR />
+
-
**[[5nuh]] - hTK Hck SH3 domain + SIV NEF<BR />
+
-
**[[4orz]] - hTK Hck SH3 domain (mutant) + HIV NEF + single domain antibody<br />
+
-
**[[3nhn]] - hTK Hck SH3-SH2-linker domain <BR />
+
-
**[[4u5w]] - hTK Hck SH3-SH2 domains + NEF <br />
+
-
**[[2c0i]], [[2c0o]], [[2c0t]] - hTK Hck SH3-SH2-SH1 domain + inhibitor<BR />
+
-
**[[5h0b]], [[5h0e]], [[5h0g]], [[5h0h]] - hTK Hck SH3-SH2-SH1 domain (mutant) + inhibitor<BR />
+
-
**[[2hk5]], [[5zj6]] - hTK Hck kinase domain + inhibitor<BR />
+
-
**[[1qcf]], [[3vrz]], [[3vs0]], [[3vs3]], [[3vs4]], [[3vs5]], [[3vs6]], [[3vs7]] - hTK Hck SH3-SH2-kinase-C-terminal domain + inhibitor<BR />
+
-
**[[3vry]], [[3vs1]], [[3vs2]] - hTK Hck SH3-SH2-kinase-C-terminal domain (mutant) + inhibitor<BR />
+
-
**[[1ad5]] - hTK Hck SH3-SH2-kinase-C-terminal domain + AMPPNP<BR />
+
-
**[[2hck]] - hTK Hck SH3-SH2-kinase-C-terminal domain + quercetin<BR />
+
-
**[[4lud]], [[4lue]] - hTK Hck SH2+SH3+kinase+C-terrminal domain (mutant) + fluorescent compound<br />
+
-
*'''Ack1 tyrosine kinase''' or '''activated cdc42 kinase 1'''
+
*'''Yes tyrosine kinase'''
-
**[[1u46]], [[4hzr]] - hTK Ack1 kinase domain <br />
+
**[[2hda]] - hTK Yes SH3 domain <br />
-
**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br />
+
**[[5mtj]] - hTK Yes SH2 domain + monobody<br />
-
**[[1u54]] - hTK Ack1 kinase domain + AMPPCP <br />
+
 
-
**[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]] - hTK Ack1 kinase domain + inhibitor<br />
+
*'''Zap-70 tyrosine kinase''' (Domains: SH2 1-259; kinase 327-606
 +
 
 +
**[[4k2r]] – hTK Zap-70<br />
 +
**[[2ozo]] - hTK Zap-70 (mutant) <br />
 +
**[[1m61]] - hTK Zap-70 SH2 domain
 +
 
 +
*Zap-70 complex
 +
 
 +
**[[2oq1]], [[4xz1]] - hTK Zap-70 SH2 domain + peptide<br />
 +
**[[4xz0]] - hTK Zap-70 SH2 domain + inhibitor<br />
 +
**[[1u59]] - hTK Zap-7kinase domain + staurosporine
 +
**[[2zva]] - mTK Lyn kinase domain + cancer drug<br />
*'''RECEPTOR TYROSINE KINASES - RTK'''
*'''RECEPTOR TYROSINE KINASES - RTK'''

Revision as of 08:54, 30 December 2020

3D structures of tyrosine kinase

Updated on 30-December-2020 - For a general description of the protein see Tyrosine kinase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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