Tyrosine kinase 3D structures

*'''Ack1 tyrosine kinase''' or '''activated cdc42 kinase 1'''

**[[1u46]], [[4hzr]] - hTK Ack1 kinase domain <br />

**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br />

**[[1u54]] - hTK Ack1 kinase domain + AMPPCP <br />

**[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]] - hTK Ack1 kinase domain + inhibitor<br />

*'''CapAB tyrosine kinase'''

**[[3bfv]] - SaTK CapA1/CapB2 – ''Staphylococcus aureus'' <br />

**[[2ved]] - SaTK CapA1/CapB2 + Mg + ADP

*'''Etk tyrosine kinase'''

**[[3cio]] - EcTK Etk kinase domain – ''Escherichia coli''<br />

*'''Fer tyrosine kinase'''

**[[2kk6]] - hTK Fer SH2 domain – NMR<BR />

**[[6kc4]] - hTK Fer SH2 domain + phosphopeptide<BR />

*'''Fes/Fps tyrosine kinase'''

**[[1wqu]], [[2dcr]] - hTK Fes SH2 domain - NMR<br />

**[[3bkb]] - hTK Fes SH2+kinase domain - NMR<br />

**[[4dyl]] - hTK Fes F-Bar domain <br />

**[[3cbl]] - hTK Fes SH2+kinase domain + peptide<br />

**[[3cd3]] - hTK Fes SH2+kinase domain + peptide + staurosporine<br />

**[[4e93]], [[6jmf]] - hTK TFes + inhibitor<br />

*'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537)

**[[1shf]], [[3ua6]] – hTK Fyn SH3 domain – human<br />

**[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]] - hTK Fyn SH3 domain (mutant)<br />

**[[1zbj]], [[1nyg]], [[1nyf]] - hTK Fyn SH3 domain – NMR<br />

**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br />

**[[4u17]] – hTK Fyn SH2 domain<br />

**[[2mrj]], [[2mqi]] – hTK Fyn SH2 domain - NMR<br />

**[[6edf]] - hTK Fyn residues 1-77<br />

**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br />

**[[3uf4]] - mTK Fyn SH2+SH3 domains<br />

**[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant) - chicken - NMR<br />

*Fyn complex

**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br />

**[[1nyf]], [[1nyg]], [[1a0n]], [[1azg]] - hTK Fyn SH3 domain + peptide – NMR<br />

**[[5zau]] - hTK Fyn SH3 domain + monobody binder – NMR<br />

**[[1efn]], [[1avz]] - hTK Fyn SH3 domain + HIV Nef protein<br />

**[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />

**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br />

**[[4d8d]], [[1efn]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />

**[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br />

**[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br />

**[[4u1p]] - hTK Fyn SH2 domain + phosphopeptide<BR />

**[[1aot]], [[1aou]], [[2mrk]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR />

**[[2dq7]] – hTK kinase domain + staurosporine<br />

*'''Hck tyrosine kinase''' Domains: SH3 81-137; SH2 119-224; SH1 or kinase+C-terminal 225-525;

**[[3hck]] - hTK Hck SH2 domain - NMR<BR />

**[[1bu1]] - hTK Hck SH3 domain <BR />

**[[4hck]], [[5hck]] - hTK Hck SH3 domain - NMR<BR />

**[[2oj2]], [[2oi3]] - hTK Hck SH3 domain + peptide - NMR<BR />

**[[3rbb]], [[3rea]], [[3reb]] - hTK Hck SH3 domain (mutant) + HIV NEF<BR />

**[[5nuh]] - hTK Hck SH3 domain + SIV NEF<BR />

**[[4orz]] - hTK Hck SH3 domain (mutant) + HIV NEF + single domain antibody<br />

**[[3nhn]] - hTK Hck SH3-SH2-linker domain <BR />

**[[4u5w]] - hTK Hck SH3-SH2 domains + NEF <br />

**[[2c0i]], [[2c0o]], [[2c0t]] - hTK Hck SH3-SH2-SH1 domain + inhibitor<BR />

**[[5h0b]], [[5h0e]], [[5h0g]], [[5h0h]] - hTK Hck SH3-SH2-SH1 domain (mutant) + inhibitor<BR />

**[[2hk5]], [[5zj6]] - hTK Hck kinase domain + inhibitor<BR />

**[[1qcf]], [[3vrz]], [[3vs0]], [[3vs3]], [[3vs4]], [[3vs5]], [[3vs6]], [[3vs7]] - hTK Hck SH3-SH2-kinase-C-terminal domain + inhibitor<BR />

**[[3vry]], [[3vs1]], [[3vs2]] - hTK Hck SH3-SH2-kinase-C-terminal domain (mutant) + inhibitor<BR />

**[[1ad5]] - hTK Hck SH3-SH2-kinase-C-terminal domain + AMPPNP<BR />

**[[2hck]] - hTK Hck SH3-SH2-kinase-C-terminal domain + quercetin<BR />

**[[4lud]], [[4lue]] - hTK Hck SH2+SH3+kinase+C-terrminal domain (mutant) + fluorescent compound<br />

*'''Itk/Tsk tyrosine kinase''' or '''interleukin-2 tyrosine kinase'''; domains – SH2 236-344; SH3 160-236; kinase 357-620

**[[2etz]], [[2eu0]] – hTK Itk SH2 domain + phosphopeptide – NMR<BR />

**[[2yuq]], [[2lmj]] – hTK Itk SH3 domain – NMR<BR />

**[[1sm2]], [[1snu]], [[1snx]] – hTK Itk kinase domain <BR />

**[[3miy]] – hTK Itk kinase domain + cancer drug<BR />

**[[3v5j]], [[3v5l]], [[3v8t]], [[3v8w]] – hTK Itk kinase domain + inhibitor<BR />

**[[3mj1]], [[3mj2]], [[3qgw]], [[3qgy]], [[4hct]], [[4hcu]], [[4hcv]], [[4kio]] – hTK Itk kinase domain (mutant) + inhibitor<BR />

**[[3t9t]] – hTK Itk kinase domain (mutant) + arthritis drug<BR />

**[[2e6i]] – hTK Itk BTK motif – NMR<BR />

**[[4l7s]], [[4m0y]], [[4m0z]], [[4m12]], [[4m13]], [[4m14]], [[4m15]], [[4mf0]], [[4mf1]], [[3v5j]], [[3v5l]], [[3v8t]], [[3v8w]] - hTK Itk kinase domain + inhibitor<br />

**[[4pp9]], [[4ppa]], [[4ppb]], [[4ppc]], [[4pqn]], [[4qd6]], [[4rfm]], [[4kio]] - hTK Itk kinase domain (mutant) + inhibitor<br />

**[[1lui]], [[1luk]], [[1lum]], [[1lun]] – mTK Itk SH2 domain – NMR<BR />

**[[3s9k]] – mTK Itk SH2 domain <BR />

**[[1awj]], [[2rn8]], [[2rna]] – mTK Itk SH3 domain – NMR<BR />

**[[2k79]], [[2k7a]] – mTK Itk SH2+SH3 domains – NMR<BR />

*'''Lymphocyte-specific tyrosine kinase Lck''' (Domains: SH3 58-118; SH2 122-225; kinase 230-500)

**[[1kik]], [[1h92]] - hTK Lck SH3 domain – NMR<BR />

**[[2iim]] - hTK Lck SH3 domain<br />

**[[4d8k]], [[1x27]] - hTK Lck SH3-SH2 domain<br />

**[[3lck]] - hTK Lck kinase domain<br />

*Lck complex

**[[1lcj]], [[1lkk]], [[1lkl]] - hTK Lck SH2 domain (mutant) + phosphopeptide<br />

**[[1cwd]], [[1cwe]], [[1ijr]] - hTK Lck SH2 domain + phosphopeptide<br />

**[[1bhf]] - hTK Lck SH2 domain + peptide inhibitor<br />

**[[1fbz]] - hTK Lck SH2 domain + inhibitor<br />

**[[1bhh]] - hTK Lck SH2 domain + T-lymphocyte-specific TK<br />

**[[5mtm]], [[5mtn]] - hTK Lck SH2 domain + monobody<br />

**[[1lck]] - hTK Lck SH3-SH2 domain (mutant) + phosphopeptide<br />

**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br />

**[[1qpj]] - hTK Lck kinase domain + staurosporin<br />

**[[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[2zm1]], [[2zm4]], [[3byo]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3kmm]], [[3ad4]], [[3ad5]], [[3ad6]], [[1qpc]], [[1qpd]], [[1qpe]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br />

**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br />

**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br />

**[[2pl0]] - hTK Lck kinase domain + anti-cancer drug<br />

**[[3kxz]] - hTK Lck kinase domain + probe molecule<br />

**[[1q68]] - hTK Lck residues 6-34 (mutant) + CD4 peptide – NMR<br />

**[[1q69]] - hTK Lck residues 6-34 (mutant) + CD8 – NMR<br />

*'''Lyn tyrosine kinase''' (Domains: SH3 39-101; SH2 115-229; kinase 239-512)

**[[4tzi]] - hTK Lyn SH2 domain <br />

**[[6nmw]] - hTK Lyn SH3 domain <br />

**[[1w1f]] - hTK Lyn SH3 domain – NMR<br />

**[[1wa7]] - hTK Lyn SH3 domain + peptide – NMR<br />

**[[3a4o]] - hTK Lyn residues 233-512 + staurosporine<br />

**[[5xy1]] - hTK Lyn kinase domain + inhibitor<br />

**[[2zv7]] - mTK Lyn kinase domain<br />

**[[2zv8]] - mTK Lyn kinase domain + AMPPNP<br />

**[[2zv9]] - mTK Lyn kinase domain + PP2<br />

**[[2zva]] - mTK Lyn kinase domain + cancer drug<br />

*'''Ptk6 tyrosine kinase or breast tumor kinase Brk or tyrosine protein kinase 6'''

**[[1rja]] - hTK Ptk6 SH2 domain – NMR<br />

**[[2kgt]] - hTK Ptk6 SH3 domain – NMR<br />

**[[5d7v]], [[6cz2]] - hTK Ptk6 kinase domain <br />

**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br />

**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br />

*'''Ptk7 tyrosine kinase'''

**[[6vg3]] - hTK Ptk7 kinase domain<br />

*'''PtkA tyrosine kinase'''

**[[6f2x]] - TK PtkA – ''Mycobacterium tuberculosis'' - NMR<br />

*'''Pyk2 tyrosine kinase or protein-tyrosine kinase 2-β (Domains: kinase 414-692; FAT 861-1009)'''

**[[3cc6]], [[3fzo]] - hTK Pyk2 kinase domain <br />

**[[3gm2]] - hTK Pyk2 FAT domain<br />

**[[3gm3]] - hTK Pyk2 FAT domain (mutant)<br />

**[[4eku]] – hTK Pyk2 FERM domain<br />

**[[2lk4]] - hTK Pyk2 FAT domain – NMR<br />

*Pyk2 complex

**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br />

**[[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[3et7]], [[5to8]], [[5tob]], [[4h1j]], [[4h1m]] - hTK Pyk2 kinase domain + inhibitor<br />

**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br />

**[[4xek]], [[4xev]], [[4xef]] - hTK Pyk2 FAT domain + leupaxin peptide<br />

**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br />

**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br />

**[[4h1m]] - hFAK2 kinase domain + indole inhibitor<br />

**[[3u3f]] – hFAK2 FAT domain (mutant) + paxillin LD2 motif<br />

*'''Ros tyrosine kinase'''

**[[3zbf]] - hTK Ros kinase domain + cancer drug<br />

**[[4uxl]] - hTK Ros kinase domain + inhibitor<br />

*'''Txk tyrosine kinase'''

**[[2dm0]] - hTK Txk SH2 domain – NMR<br />

*'''Wzc tyrosine kinase'''

**[[3la6]] - EcTK Wzc kinase domain <br />

*'''Yes tyrosine kinase'''

**[[2hda]] - hTK Yes SH3 domain <br />

**[[5mtj]] - hTK Yes SH2 domain + monobody<br />

 

 

**[[4k2r]] – hTK Zap-70<br />

**[[2ozo]] - hTK Zap-70 (mutant) <br />

**[[1m61]] - hTK Zap-70 SH2 domain

 

 

**[[2oq1]], [[4xz1]] - hTK Zap-70 SH2 domain + peptide<br />

**[[4xz0]] - hTK Zap-70 SH2 domain + inhibitor<br />

**[[1u59]] - hTK Zap-7kinase domain + staurosporine

**[[2zva]] - mTK Lyn kinase domain + cancer drug<br />

*'''Bone marrow tyrosine kinase'''; Domains – kinase 411-675

**[[2ekx]] - hTK Bmx SH2 domain – NMR<BR />

**[[2ys2]] - hTK Bmx Btk motif – NMR<BR />

*Bone marrow tyrosine kinase complex

**[[3sxr]] - hTK Bmx kinase domain (mutant) + anti-cancer drug<br />

**[[3sxs]], [[6i99]] - hTK Bmx kinase domain (mutant) + inhibitor<br />

*'''Cbl-c tyrosine kinase''' or '''signal transduction protein Cbl-c'''

**[[3vrn]] - hTK Cbl-c kinase domain <br />

**[[3vrq]] - hTK Cbl-c kinase domain (mutant)<br />

**[[3vro]] - hTK Cbl-c kinase domain + Src peptide<br />

**[[3vrp]] - hTK Cbl-c kinase domain + EGRF peptide<br />

**[[3vrr]] - hTK Cbl-c kinase domain (mutant) + EGRF peptide<br />

**[[3op0]] - hTK Cbl-c N-terminal domain (mutant) + EGRF peptide<br />

*'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]]

*'''Flt3 tyrosine kinase'''; Domains - kinase 564-958

**[[1rjb]] - hTK Flt3 kinase domain <br />

**[[4rt7]], [[6il3]], [[5x02]] - hTK Flt3 kinase domain + inhibitor<br />

**[[4xuf]], [[6jqr]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br />

**[[3qs9]], [[3qs7]] - hTK Flt3 residues 27-540 + SL cytokine <br />

*'''Matk tyrosine kinase''' or '''megakaryocyte-associated tyrosine-protein kinase'''

**[[3us4]] - hTK Matk SH2 domain <br />

*'''c-Met tyrosine kinase''' see [[Hepatocyte growth factor receptor]]

*'''Sgk223 tyrosine kinase or sugen kinase'''

 

**[[5ve6]] - hTK <br />

 

*'''Tie2 tyrosine kinase'''

 

**[[1fvr]] - hTK Tie2 kinase domain <br />