Ubiquitin

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Line 20: Line 20:
* Ubiquitin
* Ubiquitin
-
**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]], [[5ujl]] – hUBB – NMR - human<br />
+
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]], [[4wzp]], [[5k9p]], [[4zqs]], [[5dk8]], [[4xof]], [[4xok]], [[4xol]], [[4zpz]] - hUBB - human<br />
-
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]], [[4wzp]], [[5k9p]], [[4zqs]], [[5dk8]], [[4xof]], [[4xok]], [[4xol]], [[4zpz]] - hUBB<br />
+
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]], [[4pij]], [[4pih]], [[4pig]] - hUBB (mutant)<br />
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]], [[4pij]], [[4pih]], [[4pig]] - hUBB (mutant)<br />
 +
**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]], [[5ujl]] – hUBB – NMR<br />
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
**[[2m0x]] - hUBB - engineered – NMR<br />
**[[2m0x]] - hUBB - engineered – NMR<br />
 +
**[[6gf1]] - hUBB D<br />
 +
**[[6gf2]] - hUBB D - NMR<br />
**[[1gjz]], [[2l3z]] – hUBB N-terminal – NMR<br />
**[[1gjz]], [[2l3z]] – hUBB N-terminal – NMR<br />
**[[1e0q]] - hUBB N-terminal (mutant) – NMR<br />
**[[1e0q]] - hUBB N-terminal (mutant) – NMR<br />
**[[3q3f]] – hUBB/ribonuclease<br />
**[[3q3f]] – hUBB/ribonuclease<br />
 +
**[[2zcc]] – bUBB - bovine<br />
**[[2k39]] – fUBB – frog – NMR<br />
**[[2k39]] – fUBB – frog – NMR<br />
**[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br />
**[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br />
**[[1cmx]] – yUBB (modified)<br />
**[[1cmx]] – yUBB (modified)<br />
-
**[[2zcc]] – bUBB - bovine<br />
+
**[[6kna]] – UBB - polyhedrosis virus - NMR<br />
* Ubiquitin+1 mutant
* Ubiquitin+1 mutant
Line 59: Line 62:
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
**[[4s1z]] – hDiUBB + ZranB1<br />
**[[4s1z]] – hDiUBB + ZranB1<br />
 +
**[[6njd]] – hDiUBB + RavD<br />
 +
**[[6isu]] – hDiUBB + UCHL3<br />
**[[5e6j]] – hDiUBB (mutant) + replicase polyprotein<br />
**[[5e6j]] – hDiUBB (mutant) + replicase polyprotein<br />
**[[2n13]] – hDiUBB + myosin peptide - NMR<br />
**[[2n13]] – hDiUBB + myosin peptide - NMR<br />
Line 67: Line 72:
**[[2znv]] – mDiUBB+hAMSH-like protease<br />
**[[2znv]] – mDiUBB+hAMSH-like protease<br />
**[[2kde]], [[2kdf]] – fDiUBB+26S proteasome non-ATPase regulatory subunit - NMR<br />
**[[2kde]], [[2kdf]] – fDiUBB+26S proteasome non-ATPase regulatory subunit - NMR<br />
 +
**[[6jwi]] – yDiUBB + Npl4<br />
* Ubiquitin trimer
* Ubiquitin trimer
-
**[[5go7]], [[5gok]], [[5jby]], [[5jbv]] – hTriUBB <br />
+
**[[5go7]], [[5gok]], [[5jby]], [[5jbv]], [[6oq1]] – hTriUBB <br />
**[[3zlz]], [[5o44]] – hTriUBB (mutant) <br />
**[[3zlz]], [[5o44]] – hTriUBB (mutant) <br />
 +
**[[6oq2]] – hTriUBB - NMR<br />
**[[4boz]] – hTriUBB + UBB thiolesterase <br />
**[[4boz]] – hTriUBB + UBB thiolesterase <br />
**[[3vuw]], [[3vux]] – hTriUBB + TNF α-induced proitein <br />
**[[3vuw]], [[3vux]] – hTriUBB + TNF α-induced proitein <br />
Line 87: Line 94:
**[[6nxl]] – hUBB<br />
**[[6nxl]] – hUBB<br />
-
**[[4zpz]] – hUBB (mutant)<br />
+
**[[4zpz]], [[6qk9]] – hUBB (mutant)<br />
**[[5x3o]], [[3x3m]] – hUBB + d-ubiquitin <br />
**[[5x3o]], [[3x3m]] – hUBB + d-ubiquitin <br />
**[[3phd]] – hUBB + histone deacetylase 6
**[[3phd]] – hUBB + histone deacetylase 6
Line 94: Line 101:
**[[6fdk]] – hUBB + DUB1<br />
**[[6fdk]] – hUBB + DUB1<br />
**[[6ei1]], [[6fge]] – hUBB + ZUP1<br />
**[[6ei1]], [[6fge]] – hUBB + ZUP1<br />
-
**[[6cp2]] – hUBB + UBCH7 + SIDC<br />
+
**[[6cp2]] – hUBB + UbcH7 + SidC<br />
**[[6bva]], [[6byh]], [[6c16]] – hUBB + SKP1 + FBL10<br />
**[[6bva]], [[6byh]], [[6c16]] – hUBB + SKP1 + FBL10<br />
-
**[[4uf6]] – hUBB + UCH-L5 + NF-κ-b-related protein<br />
+
**[[4uf6]] – hUBB + UCHL5 + NF-κ-b-related protein<br />
**[[5vf0]] – hUBB + RAD18 - NMR<br />
**[[5vf0]] – hUBB + RAD18 - NMR<br />
**[[5vey]] – hUBB + RNF169 + Histone H2A-H2B - NMR<br />
**[[5vey]] – hUBB + RNF169 + Histone H2A-H2B - NMR<br />
**[[5n38]] , [[5n2w]], [[6glc]] – hUBB + E3 UBB protein ligase PARKIN<br />
**[[5n38]] , [[5n2w]], [[6glc]] – hUBB + E3 UBB protein ligase PARKIN<br />
 +
**[[6fyh]] – hUBB + E3 UBB protein ligase HUWE1<br />
**[[6fx4]] – hUBB (mutant) + E3 UBB protein ligase SMURF2<br />
**[[6fx4]] – hUBB (mutant) + E3 UBB protein ligase SMURF2<br />
-
**[[5mnj]] – hUBB + E3 UBB protein ligase MDM2 + UBCH5B<br />
+
**[[6hek]] – hUBB + UBB carboxyl terminal hydrolase<br />
 +
**[[5mnj]] – hUBB + E3 UBB protein ligase MDM2 + UbcH5B<br />
 +
**[[6hpr]] – hUBB + IAP1 + UbcH5B<br />
 +
**[[6njg]] – hUBB + vacuolar protein sorting-associated protein 27<br />
**[[5l8w]] – hUBB + WD repeat-containing protein 48 + USP12<br />
**[[5l8w]] – hUBB + WD repeat-containing protein 48 + USP12<br />
**[[5l8h]] – hUBB + WD repeat-containing protein 48 + USP46<br />
**[[5l8h]] – hUBB + WD repeat-containing protein 48 + USP46<br />
Line 117: Line 128:
**[[6b7m]], [[6b70]] – hUBC + SDED<br />
**[[6b7m]], [[6b70]] – hUBC + SDED<br />
**[[6aqr]] – hUBC + SAGA + UBP8 + SGF11 + SUS1 + SGF73<br />
**[[6aqr]] – hUBC + SAGA + UBP8 + SGF11 + SUS1 + SGF73<br />
 +
**[[6s53]] – hUBC + TRIM1 + UB-conjugating enzyme E2<br />
 +
**[[6t7f]] – hUBC + E3 UBB protein ligase + UB-conjugating enzyme E2<br />
* Ubiquitin monomer bound to protein
* Ubiquitin monomer bound to protein
Line 148: Line 161:
**[[4xkl]] – hUBB + NDP52<br />
**[[4xkl]] – hUBB + NDP52<br />
**[[4zfr]], [[4zft]] – hUBB + SST2<br />
**[[4zfr]], [[4zft]] – hUBB + SST2<br />
-
**[[2j7q]] – hUBB + MCMV tegument protein<br />
+
**[[2j7q]] – hUBB + McmV tegument protein<br />
**[[4dhj]], [[4dhz]] – hUBB (mutant) + UBB thiolesterase + UBB aldehyde <br />
**[[4dhj]], [[4dhz]] – hUBB (mutant) + UBB thiolesterase + UBB aldehyde <br />
**[[3rul]] – hUBB + dalvancin<br />
**[[3rul]] – hUBB + dalvancin<br />
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**[[4jio]] – hUBB + yBRO1<br />
**[[4jio]] – hUBB + yBRO1<br />
**[[5af6]] – hUBB + TRABID<br />
**[[5af6]] – hUBB + TRABID<br />
 +
**[[6q01]] – hUBB + TDP2<br />
 +
**[[6asr]] – hUBB + REV1<br />
 +
**[[6ob1]] – hUBB + WHB - NMR<br />
**[[4un2]] – hUBB + Dsk2 peptide<br />
**[[4un2]] – hUBB + Dsk2 peptide<br />
**[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br />
**[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br />
-
**[[5ln1]] – hUBB + RPN10<br />
+
**[[6q01]] – hUBB + RPN10<br />
-
**[[5v1z]], [[5v1y]] – hUBB + RPN13 + RPN2<br />
+
**[[5v1z]], [[5v1y]], [[6oi4]] – hUBB + RPN13 + RPN2<br />
**[[5jp3]] – hUBB + xanthomonas outer protein<br />
**[[5jp3]] – hUBB + xanthomonas outer protein<br />
**[[5lrw]] – hUBB (mutant)+ OUT domain containing protein 7B<br />
**[[5lrw]] – hUBB (mutant)+ OUT domain containing protein 7B<br />
Line 195: Line 211:
**[[1otr]] – yUBB+CUE2<br />
**[[1otr]] – yUBB+CUE2<br />
**[[2l00]] – yUBB + Zfand5<br />
**[[2l00]] – yUBB + Zfand5<br />
 +
**[[6oaa]], [[6oa9]] – yUBB + Npl4 + cdc48 - Cryo EM<br />
* Ubiquitin complex with ubiquitination enzymes
* Ubiquitin complex with ubiquitination enzymes
-
**[[1fxt]], [[3oj4]], [[3ugb]], [[5dfl]], [[3k9p]], [[3a33]], [[5ulf]], [[5tut]], [[6nyo]] – hUBB + UBB conjugating enzyme E2<br />
+
**[[1fxt]], [[3oj4]], [[3ugb]], [[5dfl]], [[3k9p]], [[3a33]], [[5ulf]], [[5tut]], [[6nyo]], [[6jb6]], [[6jb7]] – hUBB + UBB conjugating enzyme E2<br />
**[[5bnb]], [[2kjh]], [[1zgu]], [[6d4p]], [[6d6i]] – hUBB (mutant) + UBB conjugating enzyme E2<br />
**[[5bnb]], [[2kjh]], [[1zgu]], [[6d4p]], [[6d6i]] – hUBB (mutant) + UBB conjugating enzyme E2<br />
-
**[[5edv]], [[4whv]], [[5ait]], [[5aiu]], [[3jvz]], [[3jw0]], [[5udh]], [[5tte]] – hUBB + UBB conjugating enzyme E2 + E3 UBB-protein ligase<br />
+
**[[5edv]], [[4whv]], [[5ait]], [[5aiu]], [[3jvz]], [[3jw0]], [[5udh]], [[5tte]], [[6w9d]] – hUBB + UBB conjugating enzyme E2 + E3 UBB-protein ligase<br />
**[[2gmi]] – hUBB + UBB conjugating enzyme E2<br />
**[[2gmi]] – hUBB + UBB conjugating enzyme E2<br />
**[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
**[[2fuh]] – hUBB + UBB conjugating enzyme E2 - NMR<br />
**[[5d0k]], [[5d0m]], [[5ulk]], [[5ulh]] – hUBB + UBB conjugating enzyme E2 + RNF165<br />
**[[5d0k]], [[5d0m]], [[5ulk]], [[5ulh]] – hUBB + UBB conjugating enzyme E2 + RNF165<br />
 +
**[[6jky]], [[6kl4]], [[6p5b]], [[6ulh]], [[6ump]], [[6ums]], [[7bxg]] – hUBB + UBB conjugating enzyme E2 + MvcA<br />
 +
**[[6n13]] – hUBB + UBB conjugating enzyme E2 + parkin + phosphoUBB - NMR<br />
**[[2oob]], [[2qho]] – hUBB + E3 UBB protein ligase<br />
**[[2oob]], [[2qho]] – hUBB + E3 UBB protein ligase<br />
**[[2lvo]] – hUBB + E3 UBB protein ligase - NMR<br />
**[[2lvo]] – hUBB + E3 UBB protein ligase - NMR<br />
**[[5o76]] – hUBB + Zap70 peptide + E3-UBB-protein ligase CBL<br />
**[[5o76]] – hUBB + Zap70 peptide + E3-UBB-protein ligase CBL<br />
**[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
**[[4auq]] – hUBB + UBB conjugating enzyme E2 + livin<br />
 +
**[[6dc6]] – hUBB + UBB activating enzyme E1<br />
**[[5tr4]] – bUBB + UBB activating enzyme E1<br />
**[[5tr4]] – bUBB + UBB activating enzyme E1<br />
**[[6djw]], [[6djx]] – bUBB + UBB activating enzyme E2 + parkin<br />
**[[6djw]], [[6djx]] – bUBB + UBB activating enzyme E2 + parkin<br />
Line 217: Line 237:
* Ubiquitin + ions
* Ubiquitin + ions
-
**[[3h1u]] – bUBB+Cd<br />
 
**[[3ehv]], [[3eec]], [[3efu]] – hUBB+ions<br />
**[[3ehv]], [[3eec]], [[3efu]] – hUBB+ions<br />
**[[3n30]], [[4k7s]], [[4k7u]], [[4k7w]] – hUBB+Zn<br />
**[[3n30]], [[4k7s]], [[4k7u]], [[4k7w]] – hUBB+Zn<br />
**[[3n32]] – hUBB+Pt<br />
**[[3n32]] – hUBB+Pt<br />
 +
**[[3h1u]] – bUBB+Cd<br />
 +
 +
* Ubiquitin + small molecule
 +
 +
**[[6e2b]] – bUBB+ pyridine derivative<br />
}}
}}
==References==
==References==
<references />
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:11, 1 January 2021

Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (deep sky blue), 3k9p

Drag the structure with the mouse to rotate

3D Structures of Ubiquitin

Updated on 01-January-2021

References

  1. ↑ Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem. 1998;67:425-79. PMID:9759494 doi:http://dx.doi.org/10.1146/annurev.biochem.67.1.425
  2. ↑ Paul S. Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches. Bioessays. 2008 Nov;30(11-12):1172-84. doi: 10.1002/bies.20852. PMID:18937370 doi:http://dx.doi.org/10.1002/bies.20852
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