Ubiquitin protein ligase 3D structures

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Line 28: Line 28:
**[[5trb]] – hUPL RNF20 domain<br />
**[[5trb]] – hUPL RNF20 domain<br />
**[[4r7e]] – hUPL RING domain<br />
**[[4r7e]] – hUPL RING domain<br />
- 
-
*'''Ubiquitin protein ligase cereblon'''
 
- 
-
**[[5v3o]] – hCRBN + DNA damage-binding protein <br />
 
-
**[[5hxb]] – hCRBN + DNA damage-binding protein + eukaryotic peptide chain release factor<br />
 
-
**[[5fqd]] – hCRBN + DNA damage-binding protein + casein kinase I + lenalidomide<br />
 
-
**[[4tz4]] – hCRBN + DNA damage-binding protein + lenalidomide<br />
 
-
**[[6bnb]], [[6bn7]], [[6bn8]], [[6bn9]], [[6boy]] – hCRBN + DNA damage-binding protein + bromodomain-containing protein<br />
 
-
**[[3wx1]], [[3wx2]] – mCRBN thalidomide-binding domain - mouse<br />
 
-
**[[4tzc]], [[5yiz]], [[5yj0]], [[5yj1]] – mCRBN thalidomide-binding domain + thalidomide<br />
 
-
**[[4tzu]] – mCRBN thalidomide-binding domain + pomalidomide<br />
 
-
**[[4ci1]] – cCRBN + DNA damage-binding protein + thalidomide - chicken<br />
 
-
**[[4ci2]] – cCRBN + DNA damage-binding protein + lenalidomide<br />
 
-
**[[4ci3]] – cCRBN + DNA damage-binding protein + pomalidomide<br />
 
-
**[[5ami]] – MgCRBN 4 – ''Magnetospirillum griphyswaldense''<br />
 
-
**[[5amh]], [[5maj]], [[5amk]], [[4v2r]] – MgCer 4 + thalidomide<br />
 
-
**[[4v32]] – MgCRBN 4 (mutant) + thalidomide<br />
 
-
**[[4v2z]], [[4v30]], [[6r0c]], [[8r0s]], [[6r0u]], [[6r0v]], [[6r1d]] – MgCRBN 4 + thalidomide derivative<br />
 
-
**[[4v31]] – MgCRBN 4 + deoxyuridine<br />
 
-
**[[6r11]], [[6r13]], [[6r18]], [[6r19]], [[6r1a]], [[6r1c]], [[6r1k]], [[6r1w]], [[6r1x]] – MgCRBN 4 + effector<br />
 
- 
-
*'''Ubiquitin protein ligase CHFR'''
 
- 
-
**[[2xoc]], [[2xoy]], [[2xoz]] – hUPL C terminal + nucleotide<br />
 
-
**[[2xp0]] – hUPL C terminal <br />
 
*'''Ubiquitin protein ligase Cbl''' Domains:Tyr kinase-binding (TKB) 25-351;RING 358-437;WW3 399-432;catalytic 495-852; UBA 924-973-432
*'''Ubiquitin protein ligase Cbl''' Domains:Tyr kinase-binding (TKB) 25-351;RING 358-437;WW3 399-432;catalytic 495-852; UBA 924-973-432
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**[[1yvh]] – hUPL TKB domain + APS adaptor protein<br />
**[[1yvh]] – hUPL TKB domain + APS adaptor protein<br />
**[[3bum]], [[3bun]], [[3buo]], [[3buw]], [[3bux]], [[3ob1]], [[3ob2]], [[3rlf]], [[3pfv]], [[2k4d]], [[4gpl]] – hUPL TKB domain + peptide <br />
**[[3bum]], [[3bun]], [[3buo]], [[3buw]], [[3bux]], [[3ob1]], [[3ob2]], [[3rlf]], [[3pfv]], [[2k4d]], [[4gpl]] – hUPL TKB domain + peptide <br />
 +
**[[6o02]], [[6o03]] – hUPL TKB domain + monobody<br />
**[[2y1n]] – hUPL residues 47-435 + ZAP peptide <br />
**[[2y1n]] – hUPL residues 47-435 + ZAP peptide <br />
**[[5o76]] – hUPL residues 47-435 (mutant) + ZAP peptide <br />
**[[5o76]] – hUPL residues 47-435 (mutant) + ZAP peptide <br />
**[[4a49]] – hUPL RING domain + ubiquitin conjugating enzyme E2 <br />
**[[4a49]] – hUPL RING domain + ubiquitin conjugating enzyme E2 <br />
**[[5axi]] – mUPL-B TKB domain + cblin <br />
**[[5axi]] – mUPL-B TKB domain + cblin <br />
 +
 +
*'''Ubiquitin protein ligase cereblon'''
 +
 +
**[[5v3o]] – hCRBN + DNA damage-binding protein <br />
 +
**[[5hxb]] – hCRBN + DNA damage-binding protein + eukaryotic peptide chain release factor<br />
 +
**[[5fqd]] – hCRBN + DNA damage-binding protein + casein kinase I + lenalidomide<br />
 +
**[[4tz4]] – hCRBN + DNA damage-binding protein + lenalidomide<br />
 +
**[[6bnb]], [[6bn7]], [[6bn8]], [[6bn9]], [[6boy]] – hCRBN + DNA damage-binding protein + bromodomain-containing protein<br />
 +
**[[3wx1]], [[3wx2]] – mCRBN thalidomide-binding domain - mouse<br />
 +
**[[4tzc]], [[5yiz]], [[5yj0]], [[5yj1]] – mCRBN thalidomide-binding domain + thalidomide<br />
 +
**[[4tzu]] – mCRBN thalidomide-binding domain + pomalidomide<br />
 +
**[[4ci1]] – cCRBN + DNA damage-binding protein + thalidomide - chicken<br />
 +
**[[4ci2]] – cCRBN + DNA damage-binding protein + lenalidomide<br />
 +
**[[4ci3]] – cCRBN + DNA damage-binding protein + pomalidomide<br />
 +
**[[5ami]] – MgCRBN 4 – ''Magnetospirillum griphyswaldense''<br />
 +
**[[5amh]], [[5maj]], [[5amk]], [[4v2r]] – MgCer 4 + thalidomide<br />
 +
**[[4v32]] – MgCRBN 4 (mutant) + thalidomide<br />
 +
**[[4v2z]], [[4v30]], [[6r0c]], [[8r0s]], [[6r0u]], [[6r0v]], [[6r1d]] – MgCRBN 4 + thalidomide derivative<br />
 +
**[[4v31]] – MgCRBN 4 + deoxyuridine<br />
 +
**[[6r11]], [[6r13]], [[6r18]], [[6r19]], [[6r1a]], [[6r1c]], [[6r1k]], [[6r1w]], [[6r1x]] – MgCRBN 4 + effector<br />
 +
 +
*'''Ubiquitin protein ligase CHFR'''
 +
 +
**[[2xoc]], [[2xoy]], [[2xoz]] – hUPL C terminal + nucleotide<br />
 +
**[[2xp0]] – hUPL C terminal <br />
*'''Ubiquitin protein ligase CHIP'''
*'''Ubiquitin protein ligase CHIP'''
**[[4kbq]] – hUPL TPR domain + Hsc70<br />
**[[4kbq]] – hUPL TPR domain + Hsc70<br />
 +
**[[6efk]], [[6nsv]] – hUPL TPR domain + Hsc70 peptide<br />
*'''Ubiquitin protein ligase CNOT4'''
*'''Ubiquitin protein ligase CNOT4'''
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**[[2m6m]] – hUPL RING domain - NMR<br />
**[[2m6m]] – hUPL RING domain - NMR<br />
-
*'''Ubiquitin protein ligase DTX3L'''
+
*'''Ubiquitin protein ligase DTX'''
-
**[[3pg6]] – hUPL C terminal <br />
+
**[[6y5n]] – hUPL 1 RING-DTC domain <br />
 +
**[[6y5p]] – hUPL 1 RING-DTC domain + NAD<br />
 +
**[[3pg6]] – hUPL L3 C terminal <br />
*'''Ubiquitin protein ligase E3'''
*'''Ubiquitin protein ligase E3'''
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**[[6fyh]] – hUPL residues 4255-4374 (mutant) + ubiquitin<br />
**[[6fyh]] – hUPL residues 4255-4374 (mutant) + ubiquitin<br />
-
*'''Ubiquitin protein ligase IPAH'''
+
*'''Ubiquitin protein ligase IpaH'''
-
**[[5b0n]], [[5bot]] – UPL LRR domain – ''Shigella flexneri'' <br />
+
**[[5b0n]], [[5bot]] – SfUPL LRR domain – ''Shigella flexneri'' <br />
 +
**[[6lol]] – SfUPL <br />
*'''Ubiquitin protein ligase ITCHY''' Domains: C2 1-155; WW3 282-320; WW4 324-363; HECT 524-903
*'''Ubiquitin protein ligase ITCHY''' Domains: C2 1-155; WW3 282-320; WW4 324-363; HECT 524-903
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**[[5hqg]] – hUPL 2 <br />
**[[5hqg]] – hUPL 2 <br />
**[[6igq]] – hUPL 2 WD3-repeat domain + Trib peptide <br />
**[[6igq]] – hUPL 2 WD3-repeat domain + Trib peptide <br />
-
**[[6cvz]] – hUPL 3 WD3-repeat domain <br />
+
**[[6cvz]] – hUPL 3 WD40-repeat domain <br />
 +
 
 +
*'''Ubiquitin protein ligase RGLG1'''
 +
 
 +
**[[6k8b]], [[6k8a]], [[6k87]], [[6k88]], [[6k89]] – AtUPL VWA domain <br />
 +
**[[6k82]], [[6k83]], [[6k85]], [[6k86]] – AtUPL VWA domain (mutant)<br />
*'''Ubiquitin protein ligase RING2'''
*'''Ubiquitin protein ligase RING2'''
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**[[2n9o]] – hUPL 126 N-terminal - NMR<br />
**[[2n9o]] – hUPL 126 N-terminal - NMR<br />
**[[3icu]] – hUPL 128 protease-associated domain <br />
**[[3icu]] – hUPL 128 protease-associated domain <br />
-
**[[3v3l]] – hUPL 146 WWE domain <br />
+
**[[6l99]] – hUPL 144A N-terminal - NMR<br />
 +
**[[3v3l]] – hUPL 146 zinc finger <br />
**[[5d0i]] – hUPL 165 residues 255-348 <br />
**[[5d0i]] – hUPL 165 residues 255-348 <br />
**[[3l11]], [[4gb0]] – hUPL 168 RING domain <br />
**[[3l11]], [[4gb0]] – hUPL 168 RING domain <br />
Line 390: Line 401:
**[[2rsf]] – mUPL 146 WWE domain + ATP<br />
**[[2rsf]] – mUPL 146 WWE domain + ATP<br />
**[[4qpl]] – mUPL 146 RING+WWE domains + E2<br />
**[[4qpl]] – mUPL 146 RING+WWE domains + E2<br />
 +
**[[6tax]] – mUPL 213 + ATP - Cryo EM<br />
 +
**[[6tay]] – mUPL 213 (mutant) + ATP - Cryo EM<br />
*'''Ubiquitin protein ligase RSP'''
*'''Ubiquitin protein ligase RSP'''
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**[[4m3l]] – hUPL 63 coiled-coil domain <br />
**[[4m3l]] – hUPL 63 coiled-coil domain <br />
**[[4nqj]] – hUPL 69 coiled-coil domain <br />
**[[4nqj]] – hUPL 69 coiled-coil domain <br />
 +
**[[6yxe]] – hUPL 69 RING domain<br />
**[[3kb5]] – hUPL 72 PRY-SPRY domain <br />
**[[3kb5]] – hUPL 72 PRY-SPRY domain <br />
**[[2v0k]] – mUPL 21 PRY-SPRY domain <br />
**[[2v0k]] – mUPL 21 PRY-SPRY domain <br />
**[[4b8e]] – mUPL 25 PRY-SPRY domain <br />
**[[4b8e]] – mUPL 25 PRY-SPRY domain <br />
 +
**[[6fpt]] – zUPL 71 - zebrafish<br />
*'''Ubiquitin protein ligase TRIM complexes'''
*'''Ubiquitin protein ligase TRIM complexes'''
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**[[3u5n]], [[3u5o]], [[3u5p]], [[5mr8]] – hUPL 33 PHD+Bromo domain + H3-histone peptide <br />
**[[3u5n]], [[3u5o]], [[3u5p]], [[5mr8]] – hUPL 33 PHD+Bromo domain + H3-histone peptide <br />
**[[3zo0]] – mUPL 21 PRY-SPRY domain + IG γ-2A<br />
**[[3zo0]] – mUPL 21 PRY-SPRY domain + IG γ-2A<br />
 +
**[[6fq3]], [[6fql]] – zUPL 71 + RNA<br />
*'''Ubiquitin protein ligase UBR'''
*'''Ubiquitin protein ligase UBR'''
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**[[4tvr]] – hUPL 2 TUDOR + PHD domains <br />
**[[4tvr]] – hUPL 2 TUDOR + PHD domains <br />
**[[2zkg]] – mUPL 1 SRA domain <br />
**[[2zkg]] – mUPL 1 SRA domain <br />
 +
**[[6vee]] – mUPL 1 TTD domain - NMR<br />
 +
**[[6vfo]] – mUPL 1 PHD finger - NMR <br />
*Ubiquitin protein ligase UHRF complex
*Ubiquitin protein ligase UHRF complex

Revision as of 10:54, 5 January 2021

3D Structures of ubiquitin protein ligase

Updated on 05-January-2021 - For a general description of the protein see Ubiquitin protein ligase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky

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