1wxr

From Proteopedia

(Difference between revisions)

Revision as of 09:30, 6 January 2021

Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli

Structural highlights

1wxr is a 1 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	HBP ("Bacillus coli" Migula 1895)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HBP_ECOLX] Interacts with hemoglobin, degrades it and subsequently binds the released heme. Could make heme accessible not only for E.coli, but also for B.fragilis during mixed intra-abdominal infections. Has a role in abscess formation.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The acquisition of iron is essential for the survival of pathogenic bacteria, which have consequently evolved a wide variety of uptake systems to extract iron and heme from host proteins such as hemoglobin. Hemoglobin protease (Hbp) was discovered as a factor involved in the symbiosis of pathogenic Escherichia coli and Bacteroides fragilis, which cause intra-abdominal abscesses. Released from E. coli, this serine protease autotransporter degrades hemoglobin and delivers heme to both bacterial species. The crystal structure of the complete passenger domain of Hbp (110 kDa) is presented, which is the first structure from this class of serine proteases and the largest parallel beta-helical structure yet solved.

Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli.,Otto BR, Sijbrandi R, Luirink J, Oudega B, Heddle JG, Mizutani K, Park SY, Tame JR J Biol Chem. 2005 Apr 29;280(17):17339-45. Epub 2005 Feb 22. PMID:15728184^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Otto BR, van Dooren SJ, Nuijens JH, Luirink J, Oudega B. Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1. J Exp Med. 1998 Sep 21;188(6):1091-1103. PMID:9743528
↑ Otto BR, van Dooren SJ, Dozois CM, Luirink J, Oudega B. Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis. Infect Immun. 2002 Jan;70(1):5-10. PMID:11748157
↑ Otto BR, Sijbrandi R, Luirink J, Oudega B, Heddle JG, Mizutani K, Park SY, Tame JR. Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli. J Biol Chem. 2005 Apr 29;280(17):17339-45. Epub 2005 Feb 22. PMID:15728184 doi:10.1074/jbc.M412885200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wxr"

@@ Line 1: / Line 1: @@
 ==Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli==
-<StructureSection load='1wxr' size='340' side='right' caption='[[1wxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='1wxr' size='340' side='right'caption='[[1wxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wxr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WXR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wxr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WXR FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxr OCA], [http://pdbe.org/1wxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wxr RCSB], [http://www.ebi.ac.uk/pdbsum/1wxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxr ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxr OCA], [http://pdbe.org/1wxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wxr RCSB], [http://www.ebi.ac.uk/pdbsum/1wxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxr ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Bacillus coli migula 1895]]
+[[Category: Large Structures]]
 [[Category: Heddle, J G]]
 [[Category: Luirink, J]]

1wxr

From Proteopedia

Revision as of 09:30, 6 January 2021

Crystal structure of Heme Binding protein, an autotransporter hemoglobine protease from pathogenic Escherichia coli

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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