1dgc

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[[Image:1dgc.gif|left|200px]]
[[Image:1dgc.gif|left|200px]]
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{{Structure
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|PDB= 1dgc |SIZE=350|CAPTION= <scene name='initialview01'>1dgc</scene>, resolution 3.000&Aring;
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The line below this paragraph, containing "STRUCTURE_1dgc", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1dgc| PDB=1dgc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgc OCA], [http://www.ebi.ac.uk/pdbsum/1dgc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dgc RCSB]</span>
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'''THE X-RAY STRUCTURE OF THE GCN4-BZIP BOUND TO ATF/CREB SITE DNA SHOWS THE COMPLEX DEPENDS ON DNA FLEXIBILITY'''
'''THE X-RAY STRUCTURE OF THE GCN4-BZIP BOUND TO ATF/CREB SITE DNA SHOWS THE COMPLEX DEPENDS ON DNA FLEXIBILITY'''
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[[Category: Koenig, P.]]
[[Category: Koenig, P.]]
[[Category: Richmond, T J.]]
[[Category: Richmond, T J.]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:49:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:41:14 2008''
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Revision as of 10:49, 2 May 2008

Image:1dgc.gif

Template:STRUCTURE 1dgc

THE X-RAY STRUCTURE OF THE GCN4-BZIP BOUND TO ATF/CREB SITE DNA SHOWS THE COMPLEX DEPENDS ON DNA FLEXIBILITY


Overview

The X-ray structure of the DNA binding domain of the yeast transcriptional activator protein GCN4 bound to a DNA fragment containing the sequence of the perfectly symmetrical ATF/CREB site has been solved to 3.0 A resolution. The architecture of this specific recognition complex supports the current model for bZIP proteins: a homodimer of parallel alpha-helices form an interhelix coiled-coil region via the leucine zipper, and the two N-terminal basic regions fit into the major groove of half sites on opposite sides of the DNA double helix. The structure shows that DNA flexibility plays the predominant role in the preservation of protein contacts with the symmetric ATF/CREB site (ATGACGTCAT) as compared to the pseudo-symmetric AP-1 target site (ATGACTCAT), overcoming the positional displacement of functional groups introduced by the additional G.C base-pair at the center of the ATF/CREB sequence.

About this Structure

1DGC is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The X-ray structure of the GCN4-bZIP bound to ATF/CREB site DNA shows the complex depends on DNA flexibility., Konig P, Richmond TJ, J Mol Biol. 1993 Sep 5;233(1):139-54. PMID:8377181 Page seeded by OCA on Fri May 2 13:49:45 2008

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