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Piezo 1 is a mechanosensitive channel which means, it can sense external mechanical forces such as fluid flow-induced shear stress,
Piezo 1 is a mechanosensitive channel which means, it can sense external mechanical forces such as fluid flow-induced shear stress,
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osmotic stress, and pressure-induced membrane stretch [1]. Moreover, “studies have demonstrated wide expression of the Piezo1 channel that enables many different types of cells to sense a diversity of “outside-in” mechanical forces, including indentation, membrane stretch, shear stress, osmotic stress, ultrasound, and compression”. Since piezo 1 channel could also be activated by traction forces, there are two different mechanisms that have been proposed to explain the mechanical activation of piezo 1 channel. These mechanisms are called “force-from-lipids” and “force-from-filaments”. [http://www.example.com link title]
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osmotic stress, and pressure-induced membrane stretch [1]. Moreover, “studies have demonstrated wide expression of the Piezo1 channel that enables many different types of cells to sense a diversity of “outside-in” mechanical forces, including indentation, membrane stretch, shear stress, osmotic stress, ultrasound, and compression”. Since piezo 1 channel could also be activated by traction forces, there are two different mechanisms that have been proposed to explain the mechanical activation of piezo 1 channel. These mechanisms are called “force-from-lipids” and “force-from-filaments”. [https://www.frontiersin.org/articles/10.3389/fphar.2019.01304/full]
For the “force-from-lipids” mechanism, membrane tension is induced by mechanical forces. This membrane tension leads to a reorganization of lipids within and surrounding the channel proteins. This reorganization of lipids results into membrane lipid-channel protein interactions that induce the channel to open. We can note that a recent study (Lin et al., 2019) gave support to this mechanism.
For the “force-from-lipids” mechanism, membrane tension is induced by mechanical forces. This membrane tension leads to a reorganization of lipids within and surrounding the channel proteins. This reorganization of lipids results into membrane lipid-channel protein interactions that induce the channel to open. We can note that a recent study (Lin et al., 2019) gave support to this mechanism.

Revision as of 20:48, 7 January 2021

Piezo 1

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References

  1. 1.0 1.1 1.2 Zhao Q, Wu K, Geng J, Chi S, Wang Y, Zhi P, Zhang M, Xiao B. Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels. Neuron. 2016 Mar 16;89(6):1248-1263. doi: 10.1016/j.neuron.2016.01.046. Epub 2016, Feb 25. PMID:26924440 doi:http://dx.doi.org/10.1016/j.neuron.2016.01.046
  2. 2.0 2.1 Parpaite T, Coste B. Piezo channels. Curr Biol. 2017 Apr 3;27(7):R250-R252. doi: 10.1016/j.cub.2017.01.048. PMID:28376327 doi:http://dx.doi.org/10.1016/j.cub.2017.01.048
  3. 3.0 3.1 Zhou, Z. (2019). Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human Diseases. 139–155. DOI 10.4236/jbm.2019.712012
  4. Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, Wu K, Liu W, Zhang T, Dong MQ, Wang J, Li X, Xiao B. Structure and mechanogating mechanism of the Piezo1 channel. Nature. 2018 Feb 22;554(7693):487-492. doi: 10.1038/nature25743. Epub 2018 Jan, 22. PMID:29469092 doi:http://dx.doi.org/10.1038/nature25743
  5. 5.0 5.1 Liang X, Howard J. Structural Biology: Piezo Senses Tension through Curvature. Curr Biol. 2018 Apr 23;28(8):R357-R359. doi: 10.1016/j.cub.2018.02.078. PMID:29689211 doi:http://dx.doi.org/10.1016/j.cub.2018.02.078
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