Sandbox Reserved 1646
From Proteopedia
(Difference between revisions)
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== Biological Function == | == Biological Function == | ||
| - | The gonadotropin releasing hormone 1 receptor is activated by GnRH which acts upon GnRHRs as the key regulator of puberty and reproduction. This peptide hormone is produced in the hypothalamus but gets secreted and acts upon GnRHRs in the anterior pituitary to exert its effects on reproductive maturation. The activation of the receptor, associates with G-proteins, leads to the releasing of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH) by activating several signaling cascades. These pathways mainly corresponds to the inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), MAPK, and adenyl cyclase pathways. | + | The gonadotropin releasing hormone 1 receptor is activated by GnRH which acts upon GnRHRs as the key regulator of puberty and reproduction. This peptide hormone is produced in the hypothalamus but gets secreted and acts upon GnRHRs in the anterior pituitary to exert its effects on reproductive maturation. The activation of the receptor, associates with G-proteins, leads to the releasing of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH) by activating several signaling cascades. These pathways mainly corresponds to the inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), MAPK, and adenyl cyclase pathways. <ref>10.1210/en.2013-1341</ref> |
== Disease == | == Disease == | ||
| - | A mutation or a dysfonctionnement of the receptor could cause disease like idiopati hypogonadotropic hypogonadism (HH) which corresponds to a hypogonadism. <ref> | + | A mutation or a dysfonctionnement of the receptor could cause disease like idiopati hypogonadotropic hypogonadism (HH) which corresponds to a hypogonadism. <ref>10.1210/jc.2003-031808</ref> |
== Relevance == | == Relevance == | ||
| - | One of the main using of the couple GnRH - GnRHR in the medicine field is for fertility preservation | + | One of the main using of the couple GnRH - GnRHR in the medicine field is for fertility preservation <ref>10.1210/en.2013-1341</ref>. Indeed a mutation of the receptor gene sometimes lead to failure of detectable ligand binding |
== Structural highlights == | == Structural highlights == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| - | 1. Torrealday, S., Lalioti, M. D., Guzeloglu-Kayisli, O. and Seli, E. (2013), Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology. doi: 10.1210/en.2013-1341 | ||
| - | 2. Meysing 1 ,A.U., Kanasaki, H., Bedecarrats,G.Y. Acierno Jr, J.S. Conn, P.M., Martin,K.A., Seminara,S.B., Hall,J.E., Crowley Jr, W.F., Kaiser,U.K. (2004), GNRHR Mutations in a Woman with Idiopathic Hypogonadotropic Hypogonadism Highlight the Differential Sensitivity of Luteinizing Hormone and Follicle-Stimulating Hormone to Gonadotropin-Releasing Hormone. doi : 10.1210/jc.2003-031808 | ||
Revision as of 14:55, 8 January 2021
| This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664. |
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Gonadotropin releasing hormone 1 receptor
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ 10.1210/en.2013-1341
- ↑ 10.1210/jc.2003-031808
- ↑ 10.1210/en.2013-1341
