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<StructureSection load='6Z1N' size='360' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='6Z1N' size='360' side='right' caption='Caption for this structure' scene=''> | ||
| + | Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of isopentenyl diphosphate (IPP) and produce linear polyprenyl diphosphate. The length of this isoprenoid carbon chain varies from short molecules like geranyl diphosphate (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein N-glycosylation. It synthesises the precursor of glycosyl carrier dolichol-phosphate. Mutations in gens coding for hcis-PT can cause severe diseases, such as retinitis pigmentosa. | ||
| + | == Structure == | ||
| - | == | + | === The hcis-PT subunits === |
| - | == | + | === The active site organization === |
| - | == | + | == Catalytical activity of the human cis-prenyltransferases == |
| - | == | + | === The elongation reaction in the hydrophobic active-site tunnel === |
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| + | === Regulation of the product length === | ||
| + | |||
| + | == Importance of the enzyme == | ||
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| + | === Product of the N-glycosilation === | ||
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| + | === Disease comprehension === | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 22:23, 12 January 2021
Heterotetrameric Cis-Prenyltransferase Complex
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