Sandbox reserved 1651

Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of isopentenyl diphosphate (IPP) and produce linear polyprenyl diphosphate. The length of this isoprenoid carbon chain varies from short molecules like geranyl diphosphate (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein N-glycosylation. It synthesises the precursor of glycosyl carrier dolichol-phosphate. Mutations in gens coding for hcis-PT can cause severe diseases, such as retinitis pigmentosa.

Structure

The hcis-PT subunits

The active site organization

Catalytical activity of the human cis-prenyltransferases

The elongation reaction in the hydrophobic active-site tunnel

Regulation of the product length

Importance of the enzyme

Product of the N-glycosilation

Disease comprehension

Structural highlights

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