1dhr

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[[Image:1dhr.gif|left|200px]]
[[Image:1dhr.gif|left|200px]]
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{{Structure
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|PDB= 1dhr |SIZE=350|CAPTION= <scene name='initialview01'>1dhr</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1dhr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] </span>
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1dhr| PDB=1dhr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dhr OCA], [http://www.ebi.ac.uk/pdbsum/1dhr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dhr RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE'''
'''CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE'''
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[[Category: Whiteley, J M.]]
[[Category: Whiteley, J M.]]
[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
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[[Category: oxidoreductase(acting on nadh or nadph)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:51:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:41:43 2008''
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Revision as of 10:51, 2 May 2008

Image:1dhr.gif

Template:STRUCTURE 1dhr

CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE


Overview

The structure of a binary complex of dihydropteridine reductase [DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase, EC 1.6.99.7] with its cofactor, NADH, has been solved and refined to a final R factor of 15.4% by using 2.3 A diffraction data. DHPR is an alpha/beta protein with a Rossmann-type dinucleotide fold for NADH binding. Insertion of an extra threonine residue in the human enzyme is associated with severe symptoms of a variant form of phenylketonuria and maps to a tightly linked sequence of secondary-structural elements near the dimer interface. Dimerization is mediated by a four-helix bundle motif (two helices from each protomer) having an unusual right-handed twist. DHPR is structurally and mechanistically distinct from dihydrofolate reductase, appearing to more closely resemble certain nicotinamide dinucleotide-requiring flavin-dependent enzymes, such as glutathione reductase.

About this Structure

1DHR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of rat liver dihydropteridine reductase., Varughese KI, Skinner MM, Whiteley JM, Matthews DA, Xuong NH, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6080-4. PMID:1631094 Page seeded by OCA on Fri May 2 13:51:32 2008

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