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== '''Activation''' ==
== '''Activation''' ==
The activation of the leptin receptor is done through the CRH2, IGD and FN III domains.
The activation of the leptin receptor is done through the CRH2, IGD and FN III domains.
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The CRH2 domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues.
The CRH2 domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues.
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The IGD domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin, but completely devoid of biological activity.
The IGD domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin, but completely devoid of biological activity.
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In the FN III domains, there are two conserved cysteines that are crucial for the activation of the receptor.
In the FN III domains, there are two conserved cysteines that are crucial for the activation of the receptor.
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In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted.
In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted.

Revision as of 16:36, 13 January 2021

3V6O: Leptin receptor-antibody complex

Leptin receptor

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References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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