1di1

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[[Image:1di1.jpg|left|200px]]
[[Image:1di1.jpg|left|200px]]
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{{Structure
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|PDB= 1di1 |SIZE=350|CAPTION= <scene name='initialview01'>1di1</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1di1", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aristolochene_synthase Aristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.9 4.2.3.9] </span>
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{{STRUCTURE_1di1| PDB=1di1 | SCENE= }}
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|RELATEDENTRY=[[1dgp|1DGP]], [[1f1l|1F1L]], [[1f1k|1F1K]], [[1f1n|1F1N]], [[1f1p|1F1P]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1di1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1di1 OCA], [http://www.ebi.ac.uk/pdbsum/1di1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1di1 RCSB]</span>
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'''CRYSTAL STRUCTURE OF ARISTOLOCHENE SYNTHASE FROM PENICILLIUM ROQUEFORTI'''
'''CRYSTAL STRUCTURE OF ARISTOLOCHENE SYNTHASE FROM PENICILLIUM ROQUEFORTI'''
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[[Category: Kang, I.]]
[[Category: Kang, I.]]
[[Category: Rynkiewicz, M J.]]
[[Category: Rynkiewicz, M J.]]
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[[Category: isoprenoid biosynthesis]]
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[[Category: Isoprenoid biosynthesis]]
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[[Category: sesquiterpene cyclase]]
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[[Category: Sesquiterpene cyclase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:51:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:41:49 2008''
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Revision as of 10:51, 2 May 2008

Image:1di1.jpg

Template:STRUCTURE 1di1

CRYSTAL STRUCTURE OF ARISTOLOCHENE SYNTHASE FROM PENICILLIUM ROQUEFORTI


Overview

The 2.5-A resolution crystal structure of recombinant aristolochene synthase from the blue cheese mold, Penicillium roqueforti, is the first of a fungal terpenoid cyclase. The structure of the enzyme reveals active site features that participate in the cyclization of the universal sesquiterpene cyclase substrate, farnesyl diphosphate, to form the bicyclic hydrocarbon aristolochene. Metal-triggered carbocation formation initiates the cyclization cascade, which proceeds through multiple complex intermediates to yield one exclusive structural and stereochemical isomer of aristolochene. Structural homology of this fungal cyclase with plant and bacterial terpenoid cyclases, despite minimal amino acid sequence identity, suggests divergence from a common, primordial ancestor in the evolution of terpene biosynthesis.

About this Structure

1DI1 is a Single protein structure of sequence from Penicillium roqueforti. Full crystallographic information is available from OCA.

Reference

Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti., Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW, J Biol Chem. 2000 Aug 18;275(33):25533-9. PMID:10825154 Page seeded by OCA on Fri May 2 13:51:54 2008

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