Sandbox Reserved 1657

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
==5CZX==
==5CZX==
<StructureSection load='5czx' size='360' side='right' caption='Crystal structure of Notch3 NRR in complex with 20358 Fab' scene=''>
<StructureSection load='5czx' size='360' side='right' caption='Crystal structure of Notch3 NRR in complex with 20358 Fab' scene=''>
- 
The neurogenic locus notch homolog protein 3 is a protein encoded by the [https://en.wikipedia.org/wiki/Notch_3 NOTCH3 gene]. There are 4 [https://en.wikipedia.org/wiki/Notch_signaling_pathway notch receptors] in [https://en.wikipedia.org/wiki/Mammal mammals], all of which are transmembrane proteins and notch signalling regulates a very diverse set of biological functions; The most commun is the [https://en.wikipedia.org/wiki/Cell_lineage#:~:text=Cell%20lineage%20denotes%20the%20developmental,that%20can%20no%20longer%20divide. cell lineage determination]. Therefore, changes in the activity of these receptors is associated with various benign and malignant diseases as [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142501/ T-ALL (T-lineage acute lymphoblastic leukemia)]. T-ALL is characterized by the uncontrolled proliferation of T-cell [https://en.wikipedia.org/wiki/Lymphoblast lymphoblasts] in the blood, the brown marrow and the tissues.
The neurogenic locus notch homolog protein 3 is a protein encoded by the [https://en.wikipedia.org/wiki/Notch_3 NOTCH3 gene]. There are 4 [https://en.wikipedia.org/wiki/Notch_signaling_pathway notch receptors] in [https://en.wikipedia.org/wiki/Mammal mammals], all of which are transmembrane proteins and notch signalling regulates a very diverse set of biological functions; The most commun is the [https://en.wikipedia.org/wiki/Cell_lineage#:~:text=Cell%20lineage%20denotes%20the%20developmental,that%20can%20no%20longer%20divide. cell lineage determination]. Therefore, changes in the activity of these receptors is associated with various benign and malignant diseases as [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142501/ T-ALL (T-lineage acute lymphoblastic leukemia)]. T-ALL is characterized by the uncontrolled proliferation of T-cell [https://en.wikipedia.org/wiki/Lymphoblast lymphoblasts] in the blood, the brown marrow and the tissues.

Revision as of 20:41, 14 January 2021

Template:5CZX

5CZX

Crystal structure of Notch3 NRR in complex with 20358 Fab

Drag the structure with the mouse to rotate

References

  1. Guo Z, Ohlstein B. Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science. 2015 Nov 20;350(6263). pii: 350/6263/aab0988. doi:, 10.1126/science.aab0988. PMID:26586765 doi:http://dx.doi.org/10.1126/science.aab0988
  2. Callahan R, Smith GH. MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways. Oncogene. 2000 Feb 21;19(8):992-1001. doi: 10.1038/sj.onc.1203276. PMID:10713682 doi:http://dx.doi.org/10.1038/sj.onc.1203276
  3. Aburjania Z, Jang S, Whitt J, Jaskula-Stzul R, Chen H, Rose JB. The Role of Notch3 in Cancer. Oncologist. 2018 Aug;23(8):900-911. doi: 10.1634/theoncologist.2017-0677. Epub, 2018 Apr 5. PMID:29622701 doi:http://dx.doi.org/10.1634/theoncologist.2017-0677
  4. 4.0 4.1 4.2 Bernasconi-Elias, P., Hu, T., Jenkins, D. et al. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene 35, 6077–6086 (2016). https://doi.org/10.1038/onc.2016.133
  5. 5.0 5.1 Aster JC, Pear WS, Blacklow SC. The Varied Roles of Notch in Cancer. Annu Rev Pathol. 2017 Jan 24;12:245-275. doi:, 10.1146/annurev-pathol-052016-100127. Epub 2016 Dec 5. PMID:27959635 doi:http://dx.doi.org/10.1146/annurev-pathol-052016-100127
Personal tools