6yn8
From Proteopedia
(Difference between revisions)
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==Human MALT1(334-719) in complex with a tetrazole containing compound== | ==Human MALT1(334-719) in complex with a tetrazole containing compound== | ||
| - | <StructureSection load='6yn8' size='340' side='right'caption='[[6yn8]]' scene=''> | + | <StructureSection load='6yn8' size='340' side='right'caption='[[6yn8]], [[Resolution|resolution]] 3.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YN8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YN8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6yn8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YN8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YN8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yn8 OCA], [http://pdbe.org/6yn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yn8 RCSB], [http://www.ebi.ac.uk/pdbsum/6yn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yn8 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OZK:3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide'>OZK</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yn8 OCA], [http://pdbe.org/6yn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yn8 RCSB], [http://www.ebi.ac.uk/pdbsum/6yn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yn8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Renatus M]] | + | [[Category: Renatus, M]] |
| + | [[Category: Active site inhibitor]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 06:02, 20 January 2021
Human MALT1(334-719) in complex with a tetrazole containing compound
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