1diy

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[[Image:1diy.gif|left|200px]]
[[Image:1diy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1diy |SIZE=350|CAPTION= <scene name='initialview01'>1diy</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1diy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1diy| PDB=1diy | SCENE= }}
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|RELATEDENTRY=[[1cvu|1CVU]], [[1ddx|1DDX]], [[1prh|1PRH]], [[1pth|1PTH]], [[1pge|1PGE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1diy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1diy OCA], [http://www.ebi.ac.uk/pdbsum/1diy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1diy RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1'''
'''CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1'''
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[[Category: Malkowski, M G.]]
[[Category: Malkowski, M G.]]
[[Category: Smith, W L.]]
[[Category: Smith, W L.]]
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[[Category: arachidonic acid]]
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[[Category: Arachidonic acid]]
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[[Category: dioxygenase]]
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[[Category: Dioxygenase]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: peroxidase]]
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[[Category: Peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:54:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:42:29 2008''
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Revision as of 10:54, 2 May 2008

Image:1diy.gif

Template:STRUCTURE 1diy

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1


Overview

Prostaglandin H synthase-1 and -2 (PGHS-1 and -2) catalyze the committed step in prostaglandin synthesis and are targets for nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin. We have determined the structure of PGHS-1 at 3 angstrom resolution with arachidonic acid (AA) bound in a chemically productive conformation. The fatty acid adopts an extended L-shaped conformation that positions the 13proS hydrogen of AA for abstraction by tyrosine-385, the likely radical donor. A space also exists for oxygen addition on the antarafacial surface of the carbon in the 11-position (C-11). While this conformation allows endoperoxide formation between C-11 and C-9, it also implies that a subsequent conformational rearrangement must occur to allow formation of the C-8/C-12 bond and to position C-15 for attack by a second molecule of oxygen.

About this Structure

1DIY is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

The productive conformation of arachidonic acid bound to prostaglandin synthase., Malkowski MG, Ginell SL, Smith WL, Garavito RM, Science. 2000 Sep 15;289(5486):1933-7. PMID:10988074 Page seeded by OCA on Fri May 2 13:54:00 2008

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