6z1t
From Proteopedia
(Difference between revisions)
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==MAP3K14 (NIK) in complex with 4S/3694== | ==MAP3K14 (NIK) in complex with 4S/3694== | ||
| - | <StructureSection load='6z1t' size='340' side='right'caption='[[6z1t]]' scene=''> | + | <StructureSection load='6z1t' size='340' side='right'caption='[[6z1t]], [[Resolution|resolution]] 2.31Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z1T FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6z1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z1T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1t OCA], [http://pdbe.org/6z1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z1t RCSB], [http://www.ebi.ac.uk/pdbsum/6z1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1t ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q55:4S/3694'>Q55</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6z1q|6z1q]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP3K14, NIK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1t OCA], [http://pdbe.org/6z1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z1t RCSB], [http://www.ebi.ac.uk/pdbsum/6z1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/M3K14_HUMAN M3K14_HUMAN]] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:15084608</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Attar R]] | + | [[Category: Mitogen-activated protein kinase kinase kinase]] |
| - | [[Category: Hynd G]] | + | [[Category: Attar, R]] |
| - | [[Category: Jacoby E]] | + | [[Category: Hynd, G]] |
| - | [[Category: Meerpoel L]] | + | [[Category: Jacoby, E]] |
| - | [[Category: Querolle O]] | + | [[Category: Meerpoel, L]] |
| - | [[Category: Stansfield I]] | + | [[Category: Querolle, O]] |
| - | [[Category: Versele M]] | + | [[Category: Stansfield, I]] |
| - | [[Category: | + | [[Category: Versele, M]] |
| + | [[Category: Vlijmen, H van]] | ||
| + | [[Category: Free energy perturbation]] | ||
| + | [[Category: Jnj64290694]] | ||
| + | [[Category: Lead optimization]] | ||
| + | [[Category: Multiple myeloma]] | ||
| + | [[Category: Nik]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:25, 20 January 2021
MAP3K14 (NIK) in complex with 4S/3694
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