1dk1

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[[Image:1dk1.gif|left|200px]]
[[Image:1dk1.gif|left|200px]]
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{{Structure
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|PDB= 1dk1 |SIZE=350|CAPTION= <scene name='initialview01'>1dk1</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1dk1", creates the "Structure Box" on the page.
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{{STRUCTURE_1dk1| PDB=1dk1 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dk1 OCA], [http://www.ebi.ac.uk/pdbsum/1dk1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dk1 RCSB]</span>
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'''DETAILED VIEW OF A KEY ELEMENT OF THE RIBOSOME ASSEMBLY: CRYSTAL STRUCTURE OF THE S15-RRNA COMPLEX'''
'''DETAILED VIEW OF A KEY ELEMENT OF THE RIBOSOME ASSEMBLY: CRYSTAL STRUCTURE OF THE S15-RRNA COMPLEX'''
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[[Category: Serganov, A.]]
[[Category: Serganov, A.]]
[[Category: Tischenko, S.]]
[[Category: Tischenko, S.]]
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[[Category: protein]]
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[[Category: Protein]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: s15]]
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[[Category: S15]]
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[[Category: x-ray]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:56:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:43:02 2008''
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Revision as of 10:56, 2 May 2008

Image:1dk1.gif

Template:STRUCTURE 1dk1

DETAILED VIEW OF A KEY ELEMENT OF THE RIBOSOME ASSEMBLY: CRYSTAL STRUCTURE OF THE S15-RRNA COMPLEX


Overview

In bacterial ribosomes, the small (30S) ribosomal subunit is composed of 16S rRNA and 21 distinct proteins. Ribosomal protein S15 is of particular interest because it binds primarily to 16S rRNA and is required for assembly of the small subunit and for intersubunit association, thus representing a key element in the assembly of a whole ribosome. Here we report the 2.8 inverted question mark resolution crystal structure of the highly conserved S15-rRNA complex. Protein S15 interacts in the minor groove with a G-U/G-C motif and a three-way junction. The latter is constrained by a conserved base triple and stacking interactions, and locked into place by magnesium ions and protein side chains, mainly through interactions with the unique three-dimensional geometry of the backbone. The present structure gives insights into the dual role of S15 in ribosome assembly and translational regulation.

About this Structure

1DK1 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the S15-rRNA complex., Nikulin A, Serganov A, Ennifar E, Tishchenko S, Nevskaya N, Shepard W, Portier C, Garber M, Ehresmann B, Ehresmann C, Nikonov S, Dumas P, Nat Struct Biol. 2000 Apr;7(4):273-7. PMID:10742169 Page seeded by OCA on Fri May 2 13:56:15 2008

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