1dkg
From Proteopedia
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'''CRYSTAL STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR GRPE BOUND TO THE ATPASE DOMAIN OF THE MOLECULAR CHAPERONE DNAK''' | '''CRYSTAL STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR GRPE BOUND TO THE ATPASE DOMAIN OF THE MOLECULAR CHAPERONE DNAK''' | ||
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[[Category: Harrison, C J.]] | [[Category: Harrison, C J.]] | ||
[[Category: Kuriyan, J.]] | [[Category: Kuriyan, J.]] | ||
| - | [[Category: | + | [[Category: Coiled-coil]] |
| - | [[Category: | + | [[Category: Grpe]] |
| - | [[Category: | + | [[Category: Hsp70]] |
| - | [[Category: | + | [[Category: Molecular chaperone]] |
| - | + | [[Category: Nucleotide exchange factor]] | |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:57:06 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:57, 2 May 2008
CRYSTAL STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR GRPE BOUND TO THE ATPASE DOMAIN OF THE MOLECULAR CHAPERONE DNAK
Overview
The crystal structure of the adenine nucleotide exchange factor GrpE in complex with the adenosine triphosphatase (ATPase) domain of Escherichia coli DnaK [heat shock protein 70 (Hsp70)] was determined at 2.8 angstrom resolution. A dimer of GrpE binds asymmetrically to a single molecule of DnaK. The structure of the nucleotide-free ATPase domain in complex with GrpE resembles closely that of the nucleotide-bound mammalian Hsp70 homolog, except for an outward rotation of one of the subdomains of the protein. This conformational change is not consistent with tight nucleotide binding. Two long alpha helices extend away from the GrpE dimer and suggest a role for GrpE in peptide release from DnaK.
About this Structure
1DKG is a Protein complex structure of sequences from Escherichia coli. The following page contains interesting information on the relation of 1DKG with [Chaperones]. Full crystallographic information is available from OCA.
Reference
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK., Harrison CJ, Hayer-Hartl M, Di Liberto M, Hartl F, Kuriyan J, Science. 1997 Apr 18;276(5311):431-5. PMID:9103205 Page seeded by OCA on Fri May 2 13:57:06 2008
