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Androgen receptor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Androgen receptor''' (AR) is a [[Nuclear receptors | + | '''Androgen receptor''' (AR) is a [[Nuclear receptors|nuclear receptor]] which is activated by testosterone or 5-α-dihydrotestosterone (DHT) [[hormone]]. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. |
| - | |nuclear receptor]] which is activated by testosterone or 5-α-dihydrotestosterone (DHT) [[hormone]]. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. | + | |
== Disease == | == Disease == | ||
Revision as of 16:38, 25 January 2021
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See Also
References
- ↑ Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5. PMID:18805694 doi:10.1016/j.bmcl.2008.09.002
Proteopedia Page Contributors and Editors (what is this?)
Cristina Benito, Michal Harel, Cristina Murga, Marta Roldan Lazaro, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, David Sánchez Fernández
