Wiskott-Aldrich syndrome protein

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*WASP
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*WASP; Domains - CRIB 242-310; WH2 430-458
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**[[1ej5]] – hWASP autoinhibited – human - NMR<br />
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**[[1ej5]] – hWASP CRIB domain + 461-492 autoinhibited – human - NMR<br />
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**[[1t84]] – hWASP autoinhibited + wiskostatin - NMR<br />
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**[[1t84]] – hWASP CRIB domain + 461-492 autoinhibited + wiskostatin - NMR<br />
**[[1cee]] – hWASP CRIB domain + CDC42 - NMR<br />
**[[1cee]] – hWASP CRIB domain + CDC42 - NMR<br />
**[[2a3z]] – hWASP WH2 domain + α-actin + DNAse I + ATP<br />
**[[2a3z]] – hWASP WH2 domain + α-actin + DNAse I + ATP<br />
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**[[4n78]] – hWASP + SRA1 + NAP 1 + BRICK1 + WIRS + ABL interactor <br />
**[[4n78]] – hWASP + SRA1 + NAP 1 + BRICK1 + WIRS + ABL interactor <br />
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*N-WASP
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*Neural WASP
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**[[1mke]], [[2ifs]] – hWASP EVH1 domain/WIP peptide - NMR<br />
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**[[1mke]], [[2ifs]] – hWASP EVH1 domain 26-147/rWIP 461-485 - NMR<br />
**[[2ff3]] – hWASP WH2-2 domain + α-actin + gelsolin domain 1<br />
**[[2ff3]] – hWASP WH2-2 domain + α-actin + gelsolin domain 1<br />
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**[[2vcp]] – hWASP WH2-1,2,C domain + α-actin<br />
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**[[2vcp]] – hWASP WH2-1,2,C domain 392-484 + α-actin<br />
**[[2lnh]] – hWASP CRIB + ESPFU + insulin receptor tyrosine kinase substrate - NMR<br />
**[[2lnh]] – hWASP CRIB + ESPFU + insulin receptor tyrosine kinase substrate - NMR<br />
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**[[3m3n]] – WASP tandem W domain + α-actin - mouse<br />
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**[[3m3n]] – WASP tandem W domain 397-444 + α-actin - mouse<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:54, 26 January 2021

Human WASP WH2 domain (pink) complex with α-actin (grey), DNAse I (green), ATP, Ca+2 and Mg+2 ions, glycerol and formic acid (PDB code 2a3z)

Drag the structure with the mouse to rotate

3D Structures of Wiskott-Aldrich syndrome protein

Updated on 26-January-2021

References

  1. Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012 Apr 26;119(17):3966-74. doi: 10.1182/blood-2010-09-308197. Epub 2012 , Mar 12. PMID:22411869 doi:http://dx.doi.org/10.1182/blood-2010-09-308197
  2. Suzuki T, Mimuro H, Suetsugu S, Miki H, Takenawa T, Sasakawa C. Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell Microbiol. 2002 Apr;4(4):223-33. PMID:11952639
  3. Notarangelo LD, Miao CH, Ochs HD. Wiskott-Aldrich syndrome. Curr Opin Hematol. 2008 Jan;15(1):30-6. PMID:18043243 doi:http://dx.doi.org/10.1097/MOH.0b013e3282f30448

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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