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1zww

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Revision as of 08:19, 27 January 2021

Crystal structure of endophilin-A1 BAR domain

Structural highlights

1zww is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	Sh3gl2, Sh3d2a (LK3 transgenic mice)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SH3G2_MOUSE] Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Endophilin has been implicated in the retrieval of membrane via endocytosis of clathrin-coated vesicles, which is crucial for the maintenance of neurotransmitter exocytosis during stimulation; both exocytosis and endocytosis are regulated by intracellular calcium levels. Here, we present the 2.3 A crystal structure of the endophilin-A1 BAR domain, which has been suggested to function in inducing and sensing membrane curvature at the site of endocytosis. Endo-BAR folds into a crescent-shaped dimer composed of two elongated, three-helix bundles. Two additional domains of 30 residues each, inserted into helix 1 at the center of the concave side of the dimer, may interfere with the proposed mode of BAR domain membrane interaction. In addition, the dimer binds 11 divalent cadmium ions in the crystal mostly with typical Ca2+ co-ordination spheres. The endophilin-1A BAR domain thus constitutes a new variant of a BAR domain, and it may link endophilin-1A BAR function to calcium regulation of endocytosis.

Crystal structure of the endophilin-A1 BAR domain.,Weissenhorn W J Mol Biol. 2005 Aug 19;351(3):653-61. PMID:16023669^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Schmidt A, Wolde M, Thiele C, Fest W, Kratzin H, Podtelejnikov AV, Witke W, Huttner WB, Soling HD. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature. 1999 Sep 9;401(6749):133-41. PMID:10490020 doi:http://dx.doi.org/10.1038/43613
↑ Weissenhorn W. Crystal structure of the endophilin-A1 BAR domain. J Mol Biol. 2005 Aug 19;351(3):653-61. PMID:16023669 doi:10.1016/j.jmb.2005.06.013

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zww"

Categories: Large Structures | Lk3 transgenic mice | Weissenhorn, W | Coiled coil | Transferase

@@ Line 1: / Line 1: @@
 ==Crystal structure of endophilin-A1 BAR domain==
-<StructureSection load='1zww' size='340' side='right' caption='[[1zww]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='1zww' size='340' side='right'caption='[[1zww]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZWW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZWW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sh3gl2, Sh3d2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sh3gl2, Sh3d2a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zww OCA], [http://pdbe.org/1zww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zww RCSB], [http://www.ebi.ac.uk/pdbsum/1zww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zww ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zww OCA], [https://pdbe.org/1zww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zww RCSB], [https://www.ebi.ac.uk/pdbsum/1zww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zww ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SH3G2_MOUSE SH3G2_MOUSE]] Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.<ref>PMID:10490020</ref>
+[[https://www.uniprot.org/uniprot/SH3G2_MOUSE SH3G2_MOUSE]] Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.<ref>PMID:10490020</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Lk3 transgenic mice]]
 [[Category: Weissenhorn, W]]
 [[Category: Coiled coil]]
 [[Category: Transferase]]

1zww

From Proteopedia

Revision as of 08:19, 27 January 2021

Crystal structure of endophilin-A1 BAR domain

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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