1zx1
From Proteopedia
(Difference between revisions)
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==Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954== | ==Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954== | ||
| - | <StructureSection load='1zx1' size='340' side='right' caption='[[1zx1]], [[Resolution|resolution]] 2.16Å' scene=''> | + | <StructureSection load='1zx1' size='340' side='right'caption='[[1zx1]], [[Resolution|resolution]] 2.16Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1zx1]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZX1 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qr1|1qr1]], [[1qr2|1qr2]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qr1|1qr1]], [[1qr2|1qr2]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zx1 OCA], [https://pdbe.org/1zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zx1 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Delft, F von]] | [[Category: Delft, F von]] | ||
Revision as of 08:19, 27 January 2021
Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954
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Categories: Human | Large Structures | Arrowsmith, C | Delft, F von | Edwards, A | Gunther, U | Jansson, A | Kavanagh, K | Kerr, D | Knox, R | Ludwig, C | Oppermann, U | Structural genomic | Sundstrom, M | Walton, R | Wu, X | Dihydronicotinamide ribose | Electrondonor | Flavin-containing | Oxidoreductase | Quinone oxidoreductase 2 | Reductions of quinone | Sgc
