2atv
From Proteopedia
(Difference between revisions)
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==The crystal structure of human RERG in the GDP bound state== | ==The crystal structure of human RERG in the GDP bound state== | ||
| - | <StructureSection load='2atv' size='340' side='right' caption='[[2atv]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='2atv' size='340' side='right'caption='[[2atv]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2atv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2atv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ATV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RERG ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RERG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2atv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atv OCA], [https://pdbe.org/2atv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2atv RCSB], [https://www.ebi.ac.uk/pdbsum/2atv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2atv ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RERG_HUMAN RERG_HUMAN]] Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Burgess, N]] | [[Category: Burgess, N]] | ||
Revision as of 08:38, 27 January 2021
The crystal structure of human RERG in the GDP bound state
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Categories: Human | Large Structures | Arrowsmith, C | Burgess, N | Delft, F von | Doyle, D | Edwards, A | Elkins, J | Gileadi, O | Structural genomic | Salah, E | Schoch, G | Sundstrom, M | Turnbull, A P | Weigelt, J | Gdp/gtp binding | Gtp hydrolysis | Rerg | Sgc | Signaling protein
