Replication protein E1

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<StructureSection load='2gxa' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA, ADP, Mg++ and Cl- (PDB code [[2gxa]])' scene=''>
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<StructureSection load='1ksx' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA, ADP, Mg++ and Cl- (PDB code [[1ksx]])' scene=''>
==Function==
==Function==
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The complex between HPV6a DBD and 18-bp DNA (PDB code [[2ayg]]) shows the binding of 2 recognition helices of the dimer to 2 successive major grooves of the target DNA making numerous contacts to the DNA backbone phosphate atoms and to its bases<ref>PMID:16914454</ref>.
The complex between HPV6a DBD and 18-bp DNA (PDB code [[2ayg]]) shows the binding of 2 recognition helices of the dimer to 2 successive major grooves of the target DNA making numerous contacts to the DNA backbone phosphate atoms and to its bases<ref>PMID:16914454</ref>.
</StructureSection>
</StructureSection>
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==3D structures of regulatory protein E2==
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==3D structures of replication protein E1==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Revision as of 10:50, 27 January 2021

Bovine papillomavirus 1 replication protein E1 complex with DNA, ADP, Mg++ and Cl- (PDB code 1ksx)

Drag the structure with the mouse to rotate

3D structures of replication protein E1

Updated on 27-January-2021

Domains: helicase 301-605; DNA-binding (DBD) 286-365

1r9w - RPE1 DBD - HPV18
1tue - RPE1 428-631 (mutant) + RPE2 TAD
2v9p - RPE1 helicase domain - BPV1
5a9k - RPE1 helicase domain - Cryo EM
2gxa - RPE1 helicase domain + DNA + ADP
1f08 - RPE1 DBD
1ksx, 1ksy - RPE1 DBD + DNA

References

  1. ↑ Wilson VG, West M, Woytek K, Rangasamy D. Papillomavirus E1 proteins: form, function, and features. Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836. PMID:12086149 doi:http://dx.doi.org/10.1023/a:1015336817836
  2. ↑ Singh N, Senapati S, Bose K. Insights into the mechanism of human papillomavirus E2-induced procaspase-8 activation and cell death. Sci Rep. 2016 Feb 24;6:21408. doi: 10.1038/srep21408. PMID:26906543 doi:http://dx.doi.org/10.1038/srep21408
  3. ↑ Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL. The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12. PMID:16914454 doi:10.1093/nar/gkl466

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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