Stimulator of interferon genes protein

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(New page: <StructureSection load='6uec' size='350' side='right' caption='UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase complex with Naphthalene derivative, DMSO and Mg+2 (PDB code 6uec...)
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== Function ==
== Function ==
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'''Stimulator of interferon genes protein''' (STING) is involved in the third step of the biosynthesis of lipid A which is a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Thus, LpxD is essential to survival of Gram-negative bacteria. It catalyzes the N-acylation of UDP-3-O-(3-hydroxytetradeanoyl)glucosamine<ref>PMID:18456814</ref>. LpxD is structurally similar to LpxA which functions as the first enzye in the lipid A biosynthesis.
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'''Stimulator of interferon genes protein''' or '''transmembrane protein 173''' (STING) is involved in the third step of the biosynthesis of lipid A which is a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Thus, LpxD is essential to survival of Gram-negative bacteria. It catalyzes the N-acylation of UDP-3-O-(3-hydroxytetradeanoyl)glucosamine<ref>PMID:18456814</ref>. LpxD is structurally similar to LpxA which functions as the first enzye in the lipid A biosynthesis.
== Relevance ==
== Relevance ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Stimulator of interferon genes protein
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*Stimulator of interferon genes protein; domains - C-di-GMP-binding 154-341
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**[[6iyf]] – pSTING - pig<br />
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**[[6nt5]] – hSTING - human - Cryo EM<br />
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**[[4kc0]] – mSTING - mouse<br />
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**[[6mx0]] – hSTING C-di-GMP-binding domain (mutant)<br />
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**[[5cf]], [[5cfr]] – aSTING – anemone<br />
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**[[6iyf]] – pSTING C-di-GMP-binding domain - pig<br />
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**[[4kc0]] – mSTING C-di-GMP-binding domain - mouse<br />
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**[[5gs5]] – rSTING C-di-GMP-binding domain - rat<br />
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**[[6nt6]] – cSTING - chicken - Cryo EM<br />
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**[[5cfo]], [[5cfr]] – aSTING – anemone<br />
*Stimulator of interferon genes protein complex
*Stimulator of interferon genes protein complex
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**[[6rm0]], [[6s86]] – hSTING + GMP derivative – human<br />
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**[[4emt]], [[4emu]], [[6rm0]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br />
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**[[6cff]] – hSTING + AMP derivative <br />
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**[[6cff]] – hSTING C-di-GMP-binding domain + AMP derivative <br />
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**[[6dnk]], [[6s26]], [[6s27]] – hSTING + GMP-AMP derivative <br />
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**[[4ksy]], [[4loh]], [[5bqx]], [[6dnk]], [[6s26]], [[6s27]] – hSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
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**[[6dxg]], [[6dxl]], [[6ukm]], [[6uku]], [[6ukv]], [[6ukw]], [[6ukx]], [[6uky]], [[6ukz]], [[6ul0]] – hSTING + agonist <br />
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**[[4loi]], [[6mx3]], [[6mxe]] – hSTING C-di-GMP-binding domain (mutant) + GMP-AMP derivative <br />
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**[[4qxo]] – hSTING + drug <br />
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**[[6dxg]], [[6dxl]], [[6ukm]], [[6uku]], [[6ukv]], [[6ukw]], [[6ukx]], [[6uky]], [[6ukz]], [[6ul0]] – hSTING C-di-GMP-binding domain + agonist <br />
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**[[6a03]], [[6a04]], [[6a05]], [[6a06]] – pSTING + ligand <br />
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**[[4qxo]] – hSTING C-di-GMP-binding domain + drug <br />
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**[[4kby]] – mSTING + GMP derivative<br />
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**[[4qxp]], [[4qxq]], [[4qxr]] – hSTING C-di-GMP-binding domain (mutant) + drug <br />
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**[[5cfl]], [[5cfm]], [[5cfq]] – aSTING + GMP derivative <br />
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**[[6a03]], [[6a04]], [[6a05]], [[6a06]] – pSTING C-di-GMP-binding domain + ligand <br />
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**[[5cfp]] – aSTING (mutant) + GMP derivative<br />
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**[[4kby]] – mSTING C-di-GMP-binding domain+ GMP derivative<br />
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**[[5cfn]] – aSTING + AMP derivative <br />
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**[[4loj]], [[4lok]], [[4yp1]] – mSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
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**[[6xnn]] – mSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
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**[[4lol]] – mSTING C-di-GMP-binding domain + drug <br />
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**[[4jc5]] – mSTING C-di-GMP-binding domain + immune activator <br />
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**[[5grm]] – rSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
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**[[6nt7]], [[6nt8]] – cSTING + GMP-AMP derivative - Cryo EM<br />
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**[[6nt9]] – cSTING + TBK1 - Cryo EM<br />
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**[[5cfl]], [[5cfm]], [[5cfq]] – aSTING C-di-GMP-binding domain + GMP derivative <br />
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**[[5cfp]] – aSTING C-di-GMP-binding domain (mutant) + GMP derivative<br />
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**[[5cfn]] – aSTING C-di-GMP-binding domain + AMP derivative <br />
}}
}}

Revision as of 09:42, 29 January 2021

UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase complex with Naphthalene derivative, DMSO and Mg+2 (PDB code 6uec)

Drag the structure with the mouse to rotate

3D structures of stimulator of interferon genes protein

Updated on 29-January-2021

References

  1. ↑ Bainbridge BW, Karimi-Naser L, Reife R, Blethen F, Ernst RK, Darveau RP. Acyl chain specificity of the acyltransferases LpxA and LpxD and substrate availability contribute to lipid A fatty acid heterogeneity in Porphyromonas gingivalis. J Bacteriol. 2008 Jul;190(13):4549-58. doi: 10.1128/JB.00234-08. Epub 2008 May 2. PMID:18456814 doi:http://dx.doi.org/10.1128/JB.00234-08
  2. ↑ Jenkins RJ, Dotson GD. Dual targeting antibacterial peptide inhibitor of early lipid A biosynthesis. ACS Chem Biol. 2012 Jul 20;7(7):1170-7. doi: 10.1021/cb300094a. Epub 2012 Apr 27. PMID:22530734 doi:http://dx.doi.org/10.1021/cb300094a
  3. ↑ Kroeck KG, Sacco MD, Smith EW, Zhang X, Shoun D, Akhtar A, Darch SE, Cohen F, Andrews LD, Knox JE, Chen Y. Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Sci Rep. 2019 Oct 29;9(1):15450. doi: 10.1038/s41598-019-51844-z. PMID:31664082 doi:http://dx.doi.org/10.1038/s41598-019-51844-z

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Michal Harel, Joel L. Sussman

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