Stimulator of interferon genes protein

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Stimulator of interferon genes protein; domains - C-di-GMP-binding 154-341
+
*Stimulator of interferon genes protein; domains - C-di-GMP-binding 154-341; PLPLRT/SD motif 342-379
**[[6nt5]] – hSTING - human - Cryo EM<br />
**[[6nt5]] – hSTING - human - Cryo EM<br />
-
**[[6mx0]] – hSTING C-di-GMP-binding domain (mutant)<br />
+
**[[4ef5]], [[4f5w]], [[4f9e]] – hSTING C-di-GMP-binding domain<br />
 +
**[[4f5e]], [[6mx0]] – hSTING C-di-GMP-binding domain (mutant)<br />
**[[6iyf]] – pSTING C-di-GMP-binding domain - pig<br />
**[[6iyf]] – pSTING C-di-GMP-binding domain - pig<br />
**[[4kc0]] – mSTING C-di-GMP-binding domain - mouse<br />
**[[4kc0]] – mSTING C-di-GMP-binding domain - mouse<br />
Line 27: Line 28:
*Stimulator of interferon genes protein complex
*Stimulator of interferon genes protein complex
-
**[[4emt]], [[4emu]], [[6rm0]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br />
+
**[[4ef4]], [[4emt]], [[4emu]], [[4f5y]], [[4f9g]], [[6rm0]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br />
-
**[[6cff]] – hSTING C-di-GMP-binding domain + AMP derivative <br />
+
**[[4f5d]] – hSTING C-di-GMP-binding domain (mutant) + GMP derivative <br />
-
**[[4ksy]], [[4loh]], [[5bqx]], [[6dnk]], [[6s26]], [[6s27]] – hSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
+
**[[6cff]], [[6cy7]] – hSTING C-di-GMP-binding domain + AMP derivative <br />
 +
**[[4ksy]], [[4loh]], [[5bqx]], [[6dnk]], [[6xnp]], [[6s26]], [[6s27]] – hSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
**[[4loi]], [[6mx3]], [[6mxe]] – hSTING C-di-GMP-binding domain (mutant) + GMP-AMP derivative <br />
**[[4loi]], [[6mx3]], [[6mxe]] – hSTING C-di-GMP-binding domain (mutant) + GMP-AMP derivative <br />
**[[6dxg]], [[6dxl]], [[6ukm]], [[6uku]], [[6ukv]], [[6ukw]], [[6ukx]], [[6uky]], [[6ukz]], [[6ul0]] – hSTING C-di-GMP-binding domain + agonist <br />
**[[6dxg]], [[6dxl]], [[6ukm]], [[6uku]], [[6ukv]], [[6ukw]], [[6ukx]], [[6uky]], [[6ukz]], [[6ul0]] – hSTING C-di-GMP-binding domain + agonist <br />
**[[4qxo]] – hSTING C-di-GMP-binding domain + drug <br />
**[[4qxo]] – hSTING C-di-GMP-binding domain + drug <br />
**[[4qxp]], [[4qxq]], [[4qxr]] – hSTING C-di-GMP-binding domain (mutant) + drug <br />
**[[4qxp]], [[4qxq]], [[4qxr]] – hSTING C-di-GMP-binding domain (mutant) + drug <br />
 +
**[[5jej]] – hSTING PLPLRT/SD motif + IRF-3 CTD <br />
 +
**[[6o8b]], [[6o8c]] – hSTING PLPLRT/SD motif (mutant) + TBK1 <br />
**[[6a03]], [[6a04]], [[6a05]], [[6a06]] – pSTING C-di-GMP-binding domain + ligand <br />
**[[6a03]], [[6a04]], [[6a05]], [[6a06]] – pSTING C-di-GMP-binding domain + ligand <br />
**[[4kby]] – mSTING C-di-GMP-binding domain+ GMP derivative<br />
**[[4kby]] – mSTING C-di-GMP-binding domain+ GMP derivative<br />

Revision as of 10:09, 29 January 2021

UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase complex with Naphthalene derivative, DMSO and Mg+2 (PDB code 6uec)

Drag the structure with the mouse to rotate

3D structures of stimulator of interferon genes protein

Updated on 29-January-2021

References

  1. ↑ Bainbridge BW, Karimi-Naser L, Reife R, Blethen F, Ernst RK, Darveau RP. Acyl chain specificity of the acyltransferases LpxA and LpxD and substrate availability contribute to lipid A fatty acid heterogeneity in Porphyromonas gingivalis. J Bacteriol. 2008 Jul;190(13):4549-58. doi: 10.1128/JB.00234-08. Epub 2008 May 2. PMID:18456814 doi:http://dx.doi.org/10.1128/JB.00234-08
  2. ↑ Jenkins RJ, Dotson GD. Dual targeting antibacterial peptide inhibitor of early lipid A biosynthesis. ACS Chem Biol. 2012 Jul 20;7(7):1170-7. doi: 10.1021/cb300094a. Epub 2012 Apr 27. PMID:22530734 doi:http://dx.doi.org/10.1021/cb300094a
  3. ↑ Kroeck KG, Sacco MD, Smith EW, Zhang X, Shoun D, Akhtar A, Darch SE, Cohen F, Andrews LD, Knox JE, Chen Y. Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Sci Rep. 2019 Oct 29;9(1):15450. doi: 10.1038/s41598-019-51844-z. PMID:31664082 doi:http://dx.doi.org/10.1038/s41598-019-51844-z

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Michal Harel, Joel L. Sussman

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