Chalcone synthase

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Revision as of 12:34, 1 February 2021

Alfalfa chalcone synthase containing sulfinoalanine complex with CoA and sulfate (PDB code 1d6h)

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Updated on 01-February-2021

↑ Yu HN, Wang L, Sun B, Gao S, Cheng AX, Lou HX. Functional characterization of a chalcone synthase from the liverwort Plagiochasma appendiculatum. Plant Cell Rep. 2015 Feb;34(2):233-45. doi: 10.1007/s00299-014-1702-8. Epub 2014 , Nov 18. PMID:25404490 doi:http://dx.doi.org/10.1007/s00299-014-1702-8
↑ Kanno S, Tomizawa A, Hiura T, Osanai Y, Shouji A, Ujibe M, Ohtake T, Kimura K, Ishikawa M. Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice. Biol Pharm Bull. 2005 Mar;28(3):527-30. doi: 10.1248/bpb.28.527. PMID:15744083 doi:http://dx.doi.org/10.1248/bpb.28.527
↑ Jez JM, Ferrer JL, Bowman ME, Dixon RA, Noel JP. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry. 2000 Feb 8;39(5):890-902. PMID:10653632

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 == Structural highlights ==
-CHS active site residues (Cys-His-Asn) and Phe interact with coenzyme A.  The Cys residue is the catalytic nucleophile tethering  the starting group and the growing polyketide chain<ref>PMID:10653632</ref>.
+<scene name='87/873790/Cv/3'>CoA binding site</scene>. The Cys residue (3-sulfinoalanine is shown in this case) is the catalytic nucleophile tethering the starting group and the growing polyketide chain<ref>PMID:10653632</ref>. Water molecules are shown as red spheres.
 </StructureSection>