1dml

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[[Image:1dml.gif|left|200px]]
[[Image:1dml.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dml |SIZE=350|CAPTION= <scene name='initialview01'>1dml</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1dml", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1dml| PDB=1dml | SCENE= }}
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|RELATEDENTRY=[[1plq|1plq]], [[1axc|1axc]], [[1b8h|1b8h]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dml OCA], [http://www.ebi.ac.uk/pdbsum/1dml PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dml RCSB]</span>
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'''CRYSTAL STRUCTURE OF HERPES SIMPLEX UL42 BOUND TO THE C-TERMINUS OF HSV POL'''
'''CRYSTAL STRUCTURE OF HERPES SIMPLEX UL42 BOUND TO THE C-TERMINUS OF HSV POL'''
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[[Category: Hogle, J M.]]
[[Category: Hogle, J M.]]
[[Category: Zuccola, H J.]]
[[Category: Zuccola, H J.]]
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[[Category: dna synthesis]]
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[[Category: Dna synthesis]]
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[[Category: herpes simplex virus]]
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[[Category: Herpes simplex virus]]
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[[Category: pcna]]
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[[Category: Pcna]]
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[[Category: processivity]]
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[[Category: Processivity]]
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[[Category: sliding clamp]]
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[[Category: Sliding clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:01:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:44:29 2008''
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Revision as of 11:01, 2 May 2008

Image:1dml.gif

Template:STRUCTURE 1dml

CRYSTAL STRUCTURE OF HERPES SIMPLEX UL42 BOUND TO THE C-TERMINUS OF HSV POL


Overview

Herpes simplex virus DNA polymerase is a heterodimer composed of a catalytic subunit, Pol, and an unusual processivity subunit, UL42, which, unlike processivity factors such as PCNA, directly binds DNA. The crystal structure of a complex of the C-terminal 36 residues of Pol bound to residues 1-319 of UL42 reveals remarkable similarities between UL42 and PCNA despite contrasting biochemical properties and lack of sequence homology. Moreover, the Pol-UL42 interaction resembles the interaction between the cell cycle regulator p21 and PCNA. The structure and previous data suggest that the UL42 monomer interacts with DNA quite differently than does multimeric toroidal PCNA. The details of the structure lead to a model for the mechanism of UL42, provide the basis for drug design, and allow modeling of other proteins that lack sequence homology with UL42 or PCNA.

About this Structure

1DML is a Protein complex structure of sequences from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase., Zuccola HJ, Filman DJ, Coen DM, Hogle JM, Mol Cell. 2000 Feb;5(2):267-78. PMID:10882068 Page seeded by OCA on Fri May 2 14:01:26 2008

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