1dmt

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[[Image:1dmt.gif|left|200px]]
[[Image:1dmt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dmt |SIZE=350|CAPTION= <scene name='initialview01'>1dmt</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1dmt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RDF:N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN'>RDF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1dmt| PDB=1dmt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dmt OCA], [http://www.ebi.ac.uk/pdbsum/1dmt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dmt RCSB]</span>
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}}
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'''STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON'''
'''STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON'''
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[[Category: Oefner, C.]]
[[Category: Oefner, C.]]
[[Category: Winkler, F K.]]
[[Category: Winkler, F K.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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[[Category: signal-anchor]]
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[[Category: Signal-anchor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:02:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:44:38 2008''
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Revision as of 11:02, 2 May 2008

Image:1dmt.gif

Template:STRUCTURE 1dmt

STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON


Overview

Neutral endopeptidase is a mammalian type II integral membrane zinc-containing endopeptidase, which degrades and inactivates a number of bioactive peptides. The range of substrates cleaved by neutral endopeptidase in vitro includes the enkephalins, substance P, endothelin, bradykinin and atrial natriuretic factor. Due to the physiological importance of neutral endopeptidase in the modulation of nociceptive and pressor responses there is considerable interest in inhibitors of this enzyme as novel analgesics and anti-hypertensive agents. Here we describe the crystal structure of the extracellular domain (residues 52-749) of human NEP complexed with the generic metalloproteinase inhibitor phosphoramidon at 2.1 A resolution. The structure reveals two multiply connected folding domains which embrace a large central cavity containing the active site. The inhibitor is bound to one side of this cavity and its binding mode provides a detailed understanding of the ligand-binding and specificity determinants.

About this Structure

1DMT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon., Oefner C, D'Arcy A, Hennig M, Winkler FK, Dale GE, J Mol Biol. 2000 Feb 18;296(2):341-9. PMID:10669592 Page seeded by OCA on Fri May 2 14:02:12 2008

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