2cs0
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of the SH2 domain of human HSH2D protein== | ==Solution structure of the SH2 domain of human HSH2D protein== | ||
| - | <StructureSection load='2cs0' size='340' side='right' caption='[[2cs0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cs0' size='340' side='right'caption='[[2cs0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cs0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cs0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CS0 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSH2D ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSH2D ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cs0 OCA], [https://pdbe.org/2cs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cs0 RCSB], [https://www.ebi.ac.uk/pdbsum/2cs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cs0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cs0 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HSH2D_HUMAN HSH2D_HUMAN]] May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.<ref>PMID:11700021</ref> <ref>PMID:12960172</ref> <ref>PMID:15284240</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hayashi, F]] | [[Category: Hayashi, F]] | ||
[[Category: Kurosaki, C]] | [[Category: Kurosaki, C]] | ||
Revision as of 11:48, 3 February 2021
Solution structure of the SH2 domain of human HSH2D protein
| |||||||||||
