2cu1
From Proteopedia
(Difference between revisions)
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==Solution structure of the PB1 domain of human protein kinase MEKK2b== | ==Solution structure of the PB1 domain of human protein kinase MEKK2b== | ||
| - | <StructureSection load='2cu1' size='340' side='right' caption='[[2cu1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cu1' size='340' side='right'caption='[[2cu1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cu1]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CU1 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP3K2, MAPKKK2, MEKK2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP3K2, MAPKKK2, MEKK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transferase Transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cu1 OCA], [https://pdbe.org/2cu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cu1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cu1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cu1 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/M3K2_HUMAN M3K2_HUMAN]] Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.<ref>PMID:10713157</ref> <ref>PMID:16001074</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Hayashi, F]] | [[Category: Hayashi, F]] | ||
Revision as of 11:50, 3 February 2021
Solution structure of the PB1 domain of human protein kinase MEKK2b
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Categories: Human | Large Structures | Transferase | Hayashi, F | Inoue, K | Nagashima, T | Structural genomic | Yokoyama, S | Mapk/erk kinase kinase 2 | Mek kinase 2 | Mekk 2 | Mitogen-activated protein kinase kinase kinase 2 | National project on protein structural and functional analyse | Nppsfa | Pb1 domain | Rsgi | Signaling protein
