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2cui
From Proteopedia
(Difference between revisions)
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==Solution structure of the 31st fibronectin type III domain of the human tenascin X== | ==Solution structure of the 31st fibronectin type III domain of the human tenascin X== | ||
| - | <StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cui' size='340' side='right'caption='[[2cui]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUI FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNXB ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNXB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [https://pdbe.org/2cui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [https://www.ebi.ac.uk/pdbsum/2cui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [https://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[https://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 11:51, 3 February 2021
Solution structure of the 31st fibronectin type III domain of the human tenascin X
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Categories: Human | Large Structures | Inoue, M | Kigawa, T | Koshiba, S | Ohnishi, S | Structural genomic | Tochio, N | Yokoyama, S | Cell adhesion | Extracellular matirx | Fibronectin type iii domain | National project on protein structural and functional analyse | Nppsfa | Rsgi | Tenascin x precursor
