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2d8u
From Proteopedia
(Difference between revisions)
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==Solution structure of the B-box domain of the human tripartite motif-containing 63 protein== | ==Solution structure of the B-box domain of the human tripartite motif-containing 63 protein== | ||
| - | <StructureSection load='2d8u' size='340' side='right' caption='[[2d8u]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2d8u' size='340' side='right'caption='[[2d8u]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2d8u]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2d8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8U FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIM63 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIM63 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8u OCA], [https://pdbe.org/2d8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8u RCSB], [https://www.ebi.ac.uk/pdbsum/2d8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8u ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8u TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 11:56, 3 February 2021
Solution structure of the B-box domain of the human tripartite motif-containing 63 protein
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Categories: Human | Large Structures | Inoue, M | Kigawa, T | Koshiba, S | Miyamoto, K | Structural genomic | Tomizawa, T | Yokoyama, S | Iris ring finger protein | Ligase | Murf1 | Muscle-specific ring finger protein 1 | National project on protein structural and functional analyse | Nppsfa | Ring finger protein 28 | Rsgi | Striated muscle ring zinc finger protein | Trim63 | Tripartite motif-containing 63 | Zf-b box
