2dbh

<StructureSection load='2dbh' size='340' side='right' caption='[[2dbh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2dbh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBH FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AB2445_D11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbh OCA], [http://pdbe.org/2dbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dbh RCSB], [http://www.ebi.ac.uk/pdbsum/2dbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbh ProSAT], [http://www.topsan.org/Proteins/RSGI/2dbh TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]