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2dgp
From Proteopedia
(Difference between revisions)
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==Solution structure of the N-terminal RNA binding domain in Bruno-like 4 RNA-binding protein== | ==Solution structure of the N-terminal RNA binding domain in Bruno-like 4 RNA-binding protein== | ||
| - | <StructureSection load='2dgp' size='340' side='right' caption='[[2dgp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2dgp' size='340' side='right'caption='[[2dgp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2dgp]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2dgp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DGP FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRUNOL4 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRUNOL4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dgp OCA], [https://pdbe.org/2dgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dgp RCSB], [https://www.ebi.ac.uk/pdbsum/2dgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dgp ProSAT], [https://www.topsan.org/Proteins/RSGI/2dgp TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CELF4_HUMAN CELF4_HUMAN]] RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.<ref>PMID:11158314</ref> <ref>PMID:12649496</ref> <ref>PMID:15009664</ref> <ref>PMID:14973222</ref> <ref>PMID:15894795</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Abe, C]] | [[Category: Abe, C]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
Revision as of 12:01, 3 February 2021
Solution structure of the N-terminal RNA binding domain in Bruno-like 4 RNA-binding protein
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