2dky
From Proteopedia
(Difference between revisions)
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==Solution structure of the SAM-domain of Rho-GTPase-activating protein 7== | ==Solution structure of the SAM-domain of Rho-GTPase-activating protein 7== | ||
| - | <StructureSection load='2dky' size='340' side='right' caption='[[2dky]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2dky' size='340' side='right'caption='[[2dky]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2dky]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2dky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKY FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dky OCA], [https://pdbe.org/2dky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dky RCSB], [https://www.ebi.ac.uk/pdbsum/2dky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dky ProSAT], [https://www.topsan.org/Proteins/RSGI/2dky TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Rho GTPase activating protein|Rho GTPase activating protein]] | + | *[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Goroncy, A K]] | [[Category: Goroncy, A K]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
Revision as of 12:06, 3 February 2021
Solution structure of the SAM-domain of Rho-GTPase-activating protein 7
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