Rabphilin

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<StructureSection load='3d2d' size='340' side='right' caption='Structure of glycosylated California poppy reticuline oxidase complex with reticuline and FAD (PDB code [[3d2d]])' scene='87/873793/Cv/1'>
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<StructureSection load='5lob' size='340' side='right' caption='Structure of glycosylated California poppy reticuline oxidase complex with reticuline and FAD (PDB code [[5lob]])' scene=''>
== Function ==
== Function ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[2cm5]], [[2cm6]] – rRab C2B domain 541-680 – rat<br />
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Domains: C2A 378-510; C2B 541-680
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[[2cm5]], [[2cm6]] – rRab C2B domain – rat<br />
[[4izk]] – rRab C2B domain - NMR<br />
[[4izk]] – rRab C2B domain - NMR<br />
[[5lo8]] – rRab C2B domain + inositol phosphate derivative<br />
[[5lo8]] – rRab C2B domain + inositol phosphate derivative<br />
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[[5lob]], [[5low]] – rRab C2AB domain + SNAP25<br />
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[[5lob]], [[5low]] – rRab C2B domain + SNAP25<br />
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[[2chd]], [[4lt7]] – rRab C2A domain 378-510 <br />
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[[2chd]], [[4lt7]] – rRab C2A domain <br />
[[4np9]], [[4ns0]] – rRab C2A domain + inositol phosphate derivative<br />
[[4np9]], [[4ns0]] – rRab C2A domain + inositol phosphate derivative<br />
[[1zbd]] – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP<br />
[[1zbd]] – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP<br />
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[[2k3h]] – mRab C2A domain 378-510 - mouse - NMR<br />
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[[2k3h]] – mRab C2A domain - mouse - NMR<br />

Revision as of 08:00, 4 February 2021

Structure of glycosylated California poppy reticuline oxidase complex with reticuline and FAD (PDB code 5lob)

Drag the structure with the mouse to rotate

3D Structures of rabphilin 3-A

Updated on 04-February-2021

Domains: C2A 378-510; C2B 541-680

2cm5, 2cm6 – rRab C2B domain – rat
4izk – rRab C2B domain - NMR
5lo8 – rRab C2B domain + inositol phosphate derivative
5lob, 5low – rRab C2B domain + SNAP25
2chd, 4lt7 – rRab C2A domain
4np9, 4ns0 – rRab C2A domain + inositol phosphate derivative
1zbd – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP
2k3h – mRab C2A domain - mouse - NMR


References

  1. ↑ Dittrich H, Kutchan TM. Molecular cloning, expression, and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):9969-73. PMID:1946465
  2. ↑ Kutchan TM, Dittrich H. Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants. J Biol Chem. 1995 Oct 13;270(41):24475-81. doi: 10.1074/jbc.270.41.24475. PMID:7592663 doi:http://dx.doi.org/10.1074/jbc.270.41.24475
  3. ↑ Morais LC, Barbosa-Filho JM, Almeida RN. Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice. J Ethnopharmacol. 1998 Aug;62(1):57-61. doi: 10.1016/s0378-8741(98)00044-0. PMID:9720612 doi:http://dx.doi.org/10.1016/s0378-8741(98)00044-0
  4. ↑ Winkler A, Lyskowski A, Riedl S, Puhl M, Kutchan TM, Macheroux P, Gruber K. A concerted mechanism for berberine bridge enzyme. Nat Chem Biol. 2008 Dec;4(12):739-41. Epub 2008 Oct 26. PMID:18953357 doi:http://dx.doi.org/10.1038/nchembio.123

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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