Protein patched homolog 1

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<StructureSection load='6rtw' size='340' side='right' caption='Glycosylated human Ptch1 ectodomain 1 (grey) complex with nanobody (green) and cholesterol hemisuccinate (PDB code [[6rtw]])' scene=''>
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<StructureSection load='6n7h' size='340' side='right' caption='Glycosylated human Ptch1 ectodomain 1 (grey) complex with nanobody (green) and cholesterol hemisuccinate (PDB code [[6n7h]])' scene=''>
== Function ==
== Function ==

Revision as of 09:56, 6 February 2021

Glycosylated human Ptch1 ectodomain 1 (grey) complex with nanobody (green) and cholesterol hemisuccinate (PDB code 6n7h)

Drag the structure with the mouse to rotate

3D Structures of protein patched homolog 1

Updated on 06-February-2021

Domains: ectodomain 1 139-428; ectodomain 2 772-1023

6dmb, 6oeu – hPtch1 – human - Cryo EM
6dmo – hPtch1 (mutant) - Cryo EM
6rvd – hPtch1 + sonic hedgehog protein - Cryo EM
6dmy, 6e1h, 6n7g, 6n7h, 6n7k, 6oev, 6rmg – hPtch1/GFP + sonic hedgehog protein - Cryo EM
6rtx – hPtch1 ectodomain 1
6rty – hPtch1 ectodomain 1 + nanobody
6rtw – hPtch1 ectodomain 1 + nanobody + cholesterol derivative
6rvc – hPtch1 ectodomain 2 + nanobody
6mg8 – Ptch1 + ligand – mouse - Cryo EM


References

  1. ↑ Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet. 2000 Nov;67(5):1047-54. doi: 10.1016/S0002-9297(07)62934-6. Epub , 2000 Sep 21. PMID:11001584 doi:http://dx.doi.org/10.1016/S0002-9297(07)62934-6
  2. ↑ Ming JE, Kaupas ME, Roessler E, Brunner HG, Golabi M, Tekin M, Stratton RF, Sujansky E, Bale SJ, Muenke M. Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly. Hum Genet. 2002 Apr;110(4):297-301. doi: 10.1007/s00439-002-0695-5. Epub 2002 Mar, 2. PMID:11941477 doi:http://dx.doi.org/10.1007/s00439-002-0695-5
  3. ↑ Jeng KS, Sheen IS, Jeng WJ, Lin CC, Lin CK, Su JC, Yu MC, Fang HY. High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma. Ann Surg Oncol. 2013 Feb;20(2):464-73. doi: 10.1245/s10434-012-2593-y. Epub 2012 , Aug 22. PMID:22911366 doi:http://dx.doi.org/10.1245/s10434-012-2593-y
  4. ↑ Wator E, Wilk P, Grudnik P. Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules. 2020 Mar 30;10(4). pii: biom10040522. doi: 10.3390/biom10040522. PMID:32235505 doi:http://dx.doi.org/10.3390/biom10040522

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Alexander Berchansky, Michal Harel

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