1doa

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[[Image:1doa.gif|left|200px]]
[[Image:1doa.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1doa| PDB=1doa | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1doa OCA], [http://www.ebi.ac.uk/pdbsum/1doa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1doa RCSB]</span>
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'''STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI'''
'''STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI'''
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[[Category: Hoffman, G R.]]
[[Category: Hoffman, G R.]]
[[Category: Nassar, N.]]
[[Category: Nassar, N.]]
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[[Category: cdc42]]
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[[Category: Cdc42]]
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[[Category: gtp-binding protein]]
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[[Category: Gtp-binding protein]]
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[[Category: rhogdi]]
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[[Category: Rhogdi]]
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[[Category: x-ray]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:04:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:45:26 2008''
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Revision as of 11:04, 2 May 2008

Image:1doa.gif

Template:STRUCTURE 1doa

STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI


Overview

The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the inhibition of both GDP dissociation and GTP hydrolysis. Second, the geranylgeranyl moiety of Cdc42 inserts into a hydrophobic pocket within the immunoglobulin-like domain of the GDI molecule leading to membrane release. The structural data demonstrate how GDIs serve as negative regulators of small GTP-binding proteins and how the isoprenoid moiety is utilized in this critical regulatory interaction.

About this Structure

1DOA is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI., Hoffman GR, Nassar N, Cerione RA, Cell. 2000 Feb 4;100(3):345-56. PMID:10676816 Page seeded by OCA on Fri May 2 14:04:45 2008

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