2do5

<StructureSection load='2do5' size='340' side='right' caption='[[2do5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2do5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DO5 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SF3B2, SAP145 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2do5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2do5 OCA], [http://pdbe.org/2do5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2do5 RCSB], [http://www.ebi.ac.uk/pdbsum/2do5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2do5 ProSAT], [http://www.topsan.org/Proteins/RSGI/2do5 TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/SF3B2_HUMAN SF3B2_HUMAN]] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]