2e1o
From Proteopedia
(Difference between revisions)
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==Solution structure of RSGI RUH-028, a homeobox domain from human cDNA== | ==Solution structure of RSGI RUH-028, a homeobox domain from human cDNA== | ||
| - | <StructureSection load='2e1o' size='340' side='right' caption='[[2e1o]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2e1o' size='340' side='right'caption='[[2e1o]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E1O FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HHEX, HEX, PRH, PRHX ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HHEX, HEX, PRH, PRHX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [https://pdbe.org/2e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [https://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HHEX_HUMAN HHEX_HUMAN]] Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Abe, T]] | [[Category: Abe, T]] | ||
[[Category: Hirota, H]] | [[Category: Hirota, H]] | ||
Revision as of 11:44, 10 February 2021
Solution structure of RSGI RUH-028, a homeobox domain from human cDNA
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Categories: Human | Large Structures | Abe, T | Hirota, H | Kawaii, S | Kigawa, T | Koshiba, S | Nakamura, A | Nameki, N | Ohnishi, S | Structural genomic | Tochio, N | Yokoyama, S | Dna binding protein | National project on protein structural and functional analyse | Nppsfa | Rsgi | Unknown function
