1doz

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[[Image:1doz.gif|left|200px]]
[[Image:1doz.gif|left|200px]]
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{{Structure
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|PDB= 1doz |SIZE=350|CAPTION= <scene name='initialview01'>1doz</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1doz", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span>
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{{STRUCTURE_1doz| PDB=1doz | SCENE= }}
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|RELATEDENTRY=[[1ak1|1AK1]], [[1c1h|1C1H]], [[1c9e|1C9E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1doz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1doz OCA], [http://www.ebi.ac.uk/pdbsum/1doz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1doz RCSB]</span>
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'''CRYSTAL STRUCTURE OF FERROCHELATASE'''
'''CRYSTAL STRUCTURE OF FERROCHELATASE'''
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[[Category: Hansson, M.]]
[[Category: Hansson, M.]]
[[Category: Lecerof, D.]]
[[Category: Lecerof, D.]]
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[[Category: pi-helix]]
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[[Category: Pi-helix]]
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[[Category: rossman fold]]
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[[Category: Rossman fold]]
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Revision as of 11:06, 2 May 2008

Image:1doz.gif

Template:STRUCTURE 1doz

CRYSTAL STRUCTURE OF FERROCHELATASE


Overview

Ferrochelatase, the enzyme catalyzing metallation of protoporphyrin IX at the terminal step of heme biosynthesis, was co-crystallized with an isomer mixture of the potent inhibitor N-methylmesoporphyrin (N-MeMP). The X-ray structure revealed the active site of the enzyme, to which only one of the isomers was bound, and for the first time allowed characterization of the mode of porphyrin macrocycle distortion by ferrochelatase. Crystallization of ferrochelatase and N-MeMP in the presence of Cu(2+) leads to metallation and demethylation of N-MeMP. A mechanism of porphyrin distortion is proposed, which assumes that the enzyme holds pyrrole rings B, C and D in a vice-like grip and forces a 36 degrees tilt on ring A.

About this Structure

1DOZ is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structural and mechanistic basis of porphyrin metallation by ferrochelatase., Lecerof D, Fodje M, Hansson A, Hansson M, Al-Karadaghi S, J Mol Biol. 2000 Mar 17;297(1):221-32. PMID:10704318 Page seeded by OCA on Fri May 2 14:06:04 2008

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