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2eg5

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==The structure of xanthosine methyltransferase==
==The structure of xanthosine methyltransferase==
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<StructureSection load='2eg5' size='340' side='right' caption='[[2eg5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='2eg5' size='340' side='right'caption='[[2eg5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2eg5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cofca Cofca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2eg5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cofca Cofca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=XTS:9-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PURINE-2,6-DIONE'>XTS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=XTS:9-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PURINE-2,6-DIONE'>XTS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2efj|2efj]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2efj|2efj]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XMT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=49390 COFCA])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XMT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=49390 COFCA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg5 OCA], [http://pdbe.org/2eg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eg5 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg5 OCA], [https://pdbe.org/2eg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2eg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/XMT1_COFCA XMT1_COFCA]] Involved in the biosynthesis of caffeine. Specific for xanthosine. Cannot use xanthosine 5'-monophosphate (XMP) as substrate. Directly produces 7-methylxanthine, and therefore the methyl transfer and nucleoside cleavage may be coupled. Catalyzes the 7-N-methylation of xanthosine, but does not have 1-N- or 3-N-methylation activity.
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[[https://www.uniprot.org/uniprot/XMT1_COFCA XMT1_COFCA]] Involved in the biosynthesis of caffeine. Specific for xanthosine. Cannot use xanthosine 5'-monophosphate (XMP) as substrate. Directly produces 7-methylxanthine, and therefore the methyl transfer and nucleoside cleavage may be coupled. Catalyzes the 7-N-methylation of xanthosine, but does not have 1-N- or 3-N-methylation activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Cofca]]
[[Category: Cofca]]
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[[Category: Large Structures]]
[[Category: McCarthy, A A]]
[[Category: McCarthy, A A]]
[[Category: McCarthy, J G]]
[[Category: McCarthy, J G]]

Revision as of 12:05, 10 February 2021

The structure of xanthosine methyltransferase

PDB ID 2eg5

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